ID A0A3P8WFA8_CYNSE Unreviewed; 897 AA.
AC A0A3P8WFA8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Myosin XIX {ECO:0000313|Ensembl:ENSCSEP00000025399.1};
GN Name=MYO19 {ECO:0000313|Ensembl:ENSCSEP00000025399.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000025399.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000025399.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000025399.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; A0A3P8WFA8; -.
DR STRING; 244447.ENSCSEP00000025399; -.
DR Ensembl; ENSCSET00000025736.1; ENSCSEP00000025399.1; ENSCSEG00000016203.1.
DR GeneTree; ENSGT00940000157382; -.
DR InParanoid; A0A3P8WFA8; -.
DR OMA; CSLETTW; -.
DR Proteomes; UP000265120; Chromosome 19.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF289; UNCONVENTIONAL MYOSIN-XIX; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 2.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 16..630
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 574..596
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 113..120
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 897 AA; 103574 MW; 0D5A64F88D4B51F3 CRC64;
LEGEIQAFLT DEDKLHTYDD LTKINPVTTT TVLKCLQARY KAKVFYTHAG CSLVALNPFQ
PMPHLYRQDV MKQYHFAPQP QELKPHIFIM AEEAYRNVQG QLEPVNQSLV VSGESGAGKT
WTSRCLMKYY ASVAASSSVT KSQGTVEKIE RRVLDSNPLM EAFGNACTLR NNNSSRFGKY
IQLQLDRYPL FGASVQTYLL EKTRVACQPA NERNFHIFYQ MMKGATEEQR KEWKMLHGQH
FAWLPKTEKE IEEDCIHETL EAMGHLGIDK ERQRQIFMVL AGLLQLGNVN VSSSVDESQT
WDIEKESKDF LEKAAELLCV PFDELWECLR VRTLKAGKQS ILKPCSQAEC RLRRDCLAKV
TYARLFEWLV KLVNKSISAD KSMWCNFIGI LDVYGFECFQ KNLLEQLCIN YANEKLQQHF
VAHYLRAQQD EYVSEGLQWS FVKYQDNQSC LDLIEGSPSI FSLLNETSRL NRTPDAKTLR
VRLEMELCNN THISWNKFSN VPHFTVAHYA GQVDYHLEGM VEKNKDPVPP ELISLLQKSE
NVLLREIFIN RDTDRLIAKD LNKITVVSKF KNSLENLMKI LNTTTPHYTR CIKPNRGCRP
LTFKKKEVLM QLTACGIVET IHISAAGFPI SNRWSSFSVR RHRQTTLVTT HGVTVEEPKF
FSPSQWSVFR GSLAAPRPAR IFLMIHLTFL VSQLDLLEHR RKKILSQCAF TVQCCWLRHQ
RRKRQTQQRS ATLIQAAVRS WLVRRKVRRY HRAAVVIQNS WRRWKVKFHR ATLTLSLPTL
QEPVTVRGWP VGLALASAAS VIVSLTPTDF QKMISMISSL NLQSTKEKYR VETNQYTKDL
ASIRAQPRIQ GSVKLHFQQS PLLHADMRPD FKSDITGFNE ILLERISSFQ NTKERLH
//
