ID   A0A3P8WH63_CYNSE        Unreviewed;       940 AA.
AC   A0A3P8WH63;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Ras/Rap GTPase-activating protein SynGAP-like {ECO:0000313|Ensembl:ENSCSEP00000023975.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000023975.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000023975.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000023975.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8WH63; -.
DR   Ensembl; ENSCSET00000024295.1; ENSCSEP00000023975.1; ENSCSEG00000015256.1.
DR   GeneTree; ENSGT00940000165433; -.
DR   Proteomes; UP000265120; Chromosome 9.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   CDD; cd04013; C2_SynGAP_like; 1.
DR   CDD; cd13262; PH_RasSynGAP-like; 1.
DR   CDD; cd05136; RasGAP_DAB2IP; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   PANTHER; PTHR10194:SF96; RAS PROTEIN ACTIVATOR LIKE-3; 1.
DR   Pfam; PF00616; RasGAP; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT   DOMAIN          47..206
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          415..608
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          120..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          713..797
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          918..940
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          807..866
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        121..143
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        740..778
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   940 AA;  105962 MW;  B9C58425F02B86FC CRC64;
     MNICQRLCSC FVTDMDEVDA AQAGTSELPR LQWAAAQEVP LWDISNCVLQ EGQILISPED
     EPTVWTRNRF NSLSNNSMQN LVDIDTECTP DHVGLPGGPR PESHGGVKAL IKRRLLENKA
     KRNSNTQLNP NAKGSRRYSS RDSLSIPMES LDLSADVTTV IRPVHSSILG EKYCFEVITS
     DSTHCFGCSS AAERDRWIED LRRAAQPNKD NIGRTENSMS LWINEAKDLP PKRRYYCELH
     LDGVLFARSS SRAVQKPSNH SGLAGDGSTS SSGGLGASGG ATGGGQIFWG EFFELDNLPC
     VSQITLHLLR EEDPKKKRHS KDETTLLPMG SVAIPLADIR GRTYQEKWYP ITPFKASSTA
     GNKELLGTQM SLRIKARFQN MKVLPMEKYK EFAEYVMVDY VEMCRNLEPL LNVKEKEELA
     GALVHVLQSI GKAKEFLIDL GGAEVERLGE KEALIFRENT LATKAIDEYM KLVGQKYLID
     TLGDFITRLY ASAENCEVDP LKCLSASDLN NNQRHLRETC EEVVQKIVDV HGSFPEELNR
     IFSSWAELCE DQGRPEISQR LISASLFLRF LCPAILSPSL FGLTQAYPES NTLRTLTLTA
     KVIQNLANFT LFGEKEEYML FMNEFLEQHW NGMRTFLQTV SSSDTEVPMT SFDGYVDLPL
     RLAVLHGLLV DIIRQKHQDT IDSLHPLPSI LNQITEFLGP EMPRILINRD VRTRKNTREK
     AQIKRTHSAP HRPTAYAKRA LKRQTSSETL PTSEPDQETE TSPLDISQPN TSVSVNRTPA
     APVPWIKNGI GKEPSEMKAE NEEFKILDRH DQELSELRLG VEQVTERELD MAKRLEDFII
     QSQDHNAMLQ AEVTELRSML AEREEQLTSA TFRLGVIEEE REEHDRNLSV ALAAVDRMNV
     LEEQFAVLMK DLQKLNEAHN SNNSGHNNTQ HPDKHHVNNV
//