ID A0A3P8WHL2_CYNSE Unreviewed; 692 AA.
AC A0A3P8WHL2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Nucleolar protein 10 {ECO:0000256|ARBA:ARBA00015517};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000026968.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000026968.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000026968.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the WD repeat NOL10/ENP2 family.
CC {ECO:0000256|ARBA:ARBA00005264}.
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DR AlphaFoldDB; A0A3P8WHL2; -.
DR STRING; 244447.ENSCSEP00000026968; -.
DR Ensembl; ENSCSET00000027330.1; ENSCSEP00000026968.1; ENSCSEG00000017227.1.
DR GeneTree; ENSGT00390000007900; -.
DR InParanoid; A0A3P8WHL2; -.
DR Proteomes; UP000265120; Chromosome 1.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR040382; NOL10/Enp2.
DR InterPro; IPR012580; NUC153.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR14927:SF0; NUCLEOLAR PROTEIN 10; 1.
DR PANTHER; PTHR14927; UNCHARACTERIZED; 1.
DR Pfam; PF08159; NUC153; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 459..485
FT /note="NUC153"
FT /evidence="ECO:0000259|Pfam:PF08159"
FT REGION 507..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..692
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 80054 MW; DF202ABB713C96A8 CRC64;
MHLSTLPLLF LNSDIQRRIE LIQDFEMPTV CTSIKVSRDG HFILAAGTYK PRVRCYDTYQ
LSLKFERCLD SDVVAFDILS DDYSKLVFLH SDRYVEFHSQ HGHYYKTRIP TFGRAFSYHY
PSCDLFFVGT SSEVFRLNLE QGRFLNSLQT EAVENNVCDI NPVHHLIATG SSEGRIECWD
PRVRNRVGTL DCALSSIREG TEVQALPSVT ALKFNNSLSM AVGTGSGQVL LYDLRSSQPL
LVKDHFYNLP IKSLHFHDQL DLVMSADSKI IKMWNKDSGK VFSSIEPPAN INDVCIYPQS
GLLFTANEDP KMNIFYIPAL GPAPRWCSFL DNLTEELEES PESTVYDDYK FVTRKDLENL
GLSHLIGSSL LRAYMHGFFM DIRLYHKVKS MVNPFAYEEY RKDKIRQKIE EARTQRVQIK
KLPKVNKELA LKLMEDGEDE AVLARRTKKG KAVPNILSDD RFKVMFENPD YQVDEQSEEF
RLLNPIVSKV GLKNKKKLRL LAQQAASLQK MNEDEDEPEG QASSEEESSD DDKSWVEEVR
EQRRLLRQED WERRRQERKN VDRNTVLLEN ARQKSSVKSE SKERSQPQFY QLKAGEEFRS
FNDVTHKQKL QKASLEDRLK LEENSETSNM ANTAVGSKQL TFTLQKSEQQ RKQQQAEREH
HEERKQLRRS AGHLSSRRGR GWGGRRGGRG RH
//
