ID A0A3P8WIH7_CYNSE Unreviewed; 738 AA.
AC A0A3P8WIH7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=ARF GTPase-activating protein GIT2-like {ECO:0000313|Ensembl:ENSCSEP00000024450.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000024450.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000024450.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000024450.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_008324091.1; XM_008325869.2.
DR AlphaFoldDB; A0A3P8WIH7; -.
DR STRING; 244447.ENSCSEP00000024450; -.
DR Ensembl; ENSCSET00000024779.1; ENSCSEP00000024450.1; ENSCSEG00000015601.1.
DR GeneID; 103390136; -.
DR GeneTree; ENSGT00940000156383; -.
DR InParanoid; A0A3P8WIH7; -.
DR OMA; RENEVNW; -.
DR OrthoDB; 2877020at2759; -.
DR Proteomes; UP000265120; Chromosome 14.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR032352; GIT1/2_CC.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR PANTHER; PTHR46097:SF2; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP 2 ISOFORM X1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF16559; GIT_CC; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 1..124
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 166..198
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 379..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 81702 MW; F40BF6D188F07A07 CRC64;
MSKRVRSREV CADCSAPEPR WASVNRGVLI CDECCSIHRG LGRHSSQVRH LTHSSWPPSQ
LQMVQTLYGN GANSIWEHSL LDPSSSVSGK RKANPQDRVH PNKTEFIKAK YQMLAYVHRM
PCREDDSVTS KDLSKQLHSS VRTGNLETCL RLLSLGAQAN FFHPEKGNSP LHIAAKAGQM
LQAELLAVYG ADPGALDSSG KTPIDYARQA GHHELAERLV EIQYELTDRL TFYLCGRRPD
HRNGQHFIIP QMADSSLDLS EFAKVAKKKL QSLSNHQFEE LAMDVYDEVD RRETDAVWLA
TQNHSTLVTD TTVVPFLPVN PEYSSTRNQG RQKLARFSAH EFATLVIDIL TDAKRRQWGN
SCESPKENVE LILQGIDSRH NSDSQDNDQP DYDSVASDED PVLEATCGDS CNDDRTKSSE
SSDLSDGPIT VQEFMEVKSA LTASEAKIQQ LLKVNCHLSE ELRMMQSKLN SLQTENTKLR
WQSPGGQQHL QAPCSRHPPR GGRAMSMYET GSAPRQYSHR GDTARHEDGV ILQPFPTNIG
RGPLGTAASS LPTFPSSLSW SRDERSRRGC SLEGRSTMLH NDSDITANHS ELEETGSPLS
ASDAGEAEAL GEKDASLPST EDVICKTEQI TKNIQELLRA AQDTKHEHFL PCSEKICVAV
TEMAALFPKR PSSDTVRSSL CLLTSSASRL HGECQKAADH SPCPSDIQLV TQQVIQCAYD
IAKAAKQLVT VTTKENNN
//
