ID A0A3P8WIR1_CYNSE Unreviewed; 1697 AA.
AC A0A3P8WIR1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Uncharacterized LOC103393819 {ECO:0000313|Ensembl:ENSCSEP00000026362.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000026362.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000026362.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000026362.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSCSET00000026715.1; ENSCSEP00000026362.1; ENSCSEG00000016812.1.
DR GeneTree; ENSGT00940000159109; -.
DR OMA; ERGEMHS; -.
DR Proteomes; UP000265120; Chromosome 18.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 4.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR18966:SF484; GLUTAMATE RECEPTOR, IONOTROPIC, N-METHYL D-ASPARTATE 2D, A; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1697
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017974444"
FT TRANSMEM 427..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 771..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 304..601
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 312..374
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 816..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1443..1479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1543..1697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..890
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..955
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..1010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1072
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1141
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1165
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1218..1245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1332..1346
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1347..1392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1548..1579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1599..1618
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1619..1658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1697 AA; 186785 MW; B75C5F4A2A23B26F CRC64;
MVAPRPALSL LLAVLACTGP SRSSPPLLLR PRERERDSGG VNIAVIHSGT SLLPETAVVG
GAGVAGGGSG EPGPGNGLGG VRGATDTTLL AGAAAMASFS SSSSSATVLS TLSLAALVSE
TVMTPSGQAN VIYLTVNESS PGSLLLQLCE LLSTTPLQES GSIYLQFTCS TALQLEVIFE
VLEEYDWTAF SVVTTRHHGY EDFLAMVEGM TDGSFIGWEK KSVVVLNVTD DPGGARTKRL
LKDNEAQVGW WENGHLRLRY HPWSRYGSFL KPLDDSQHLR VVTLEERPFV IVEPADPGTS
SCIRDSVPCR MPLNTLVVEG AGPMKHCCKG FCIDVLKRLA KIVGFTYDLY LVTNGRHGKN
IDGEWNGMVG EVVSRRADMA IGSLTINEER SEVVEFSVPF VETGISVMVS RSNGTVSPSA
FLPYSPAVWV MMFVMCLSVV AVTVFIFEFF SPVGYNRSLQ SAKVWAFFAV IFLASYTANL
AAFMIQEEYI DTVSGLSDKK FQQPTEQYPP LRFGTVPNGS TEENIRSNYP NMHQYMIRNN
QKGVEEAIDN LKTTIGSGKV FATTGYGIAL HKNSRWKRPL DLALLQLVGD SSKLDIDNMA
GVFYMLLVAM GLSLLVFAWE HLIYWKLRHC VKKSGRMDFL LALSRGMYSC CQFEDETTVG
GTTTNLPQYH TVTTMPSAPQ QHLVTATVNN TTAIAMVQQQ PQQKHHQQQQ GQTYTTMLPG
SPPNTGHSAM ALGPSNSPLL EVPMPCSTFL PRHDRRLAVV DRWNRPKTEK VIGAGSSGGV
GIGGIAGGIL DHQAQQLYQQ NLGQTWSLQG TVSGADTGQD EYKRYYGPID PEGLGSNSEQ
QTGGTQQTPK ANPHCPKASG MLRLSAKAPP QGPTQLVSKP PPPMPSSPRR PPFWRRGSLV
QPRRKGSGGP LYENILPLGR RGGGRYGVGD GVGRRSRRPP PPPPIPVPFS SPTHTPTTPS
SPCRFYSSCS SASLSSSSSS SSTSSSSSSV SLSRSNSLSS CSSDSSYNSS LGFRYRAGDR
DFMVDEDYDS DLLTEESSLL LGSRRKIRSR RMSSRSLPCS PPPPPIPPRK PRPQKGNGRE
RTSNQLAQLQ EWWASWGDRD RGRRGSTPRG NAGVGREEKR HHKEREHVRK RKKKGHKKKK
REERERERER KRHKAKKKKK REQMIQKQER KRSEQEGGDS EKRDQHKSGT PDYPLYPSLR
RESFRKKSET SFRNYGWNIP DDDDRKDREE KVRDDGEDSR GKDKRQRGRD RKHYHRSGSK
TTTSVKFWGG ENPACDTLPS AFLPLLPVSS KRRKSKSSGM DVVGMDGERK PLLGRNEGGE
IHSKEGLSFN EWESDQGEDE EEEESEQERR RLDRGKRLGG RGRMLSEDER ERDKGTEIYS
DDDGSSGEFG KFERYWEDHE GRAVGGIGGG GWFFSTYPSR DKAGSINSRD DLFLDRGDRW
GTADVGWSSS GGGGDGGERG WGSGSHWPPP PLTPPPPRRY WSVDKLHIQD EKKSKWKAKY
KGRGHTACST CLSPQHHTHS HSSKWAQVSS RSQEELFHHC QSFGGPLKLK HDSSSSSKPD
RSQSQSESAS QSNLSNQQRA QRTDRDRGRQ QSPTQTLTPT LPSPLPALPA PPSSCHPIHA
PPHTSSSSVS SPSVVSSTPG APQSSSMASA SAKLQYQRLR SVPQPHRFPQ SPHLPLKAKS
LCSRRGSAHF SSVESEV
//
