ID A0A3P8WJ96_CYNSE Unreviewed; 1036 AA.
AC A0A3P8WJ96;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=SH3 and PX domain-containing protein 2A-like {ECO:0000313|Ensembl:ENSCSEP00000024750.1};
GN Name=SH3PXD2A {ECO:0000313|Ensembl:ENSCSEP00000024750.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000024750.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000024750.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000024750.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SH3PXD2 family.
CC {ECO:0000256|ARBA:ARBA00009628}.
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DR AlphaFoldDB; A0A3P8WJ96; -.
DR Ensembl; ENSCSET00000025082.1; ENSCSEP00000024750.1; ENSCSEG00000015795.1.
DR GeneTree; ENSGT00940000157732; -.
DR Proteomes; UP000265120; Chromosome 12.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06888; PX_FISH; 1.
DR CDD; cd12074; SH3_Tks5_1; 1.
DR CDD; cd12077; SH3_Tks5_2; 1.
DR CDD; cd12019; SH3_Tks5_4; 1.
DR CDD; cd12020; SH3_Tks5_5; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR037961; SH3PXD2_PX.
DR InterPro; IPR035450; SH3PXD2A_SH3_1.
DR InterPro; IPR035452; SH3PXD2A_SH3_2.
DR InterPro; IPR035453; SH3PXD2A_SH3_4.
DR InterPro; IPR035454; SH3PXD2A_SH3_5.
DR PANTHER; PTHR15706:SF2; SH3 AND PX DOMAIN-CONTAINING PROTEIN 2B; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 2.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 5.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 4..128
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 151..210
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 223..282
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 402..461
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 741..800
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 975..1036
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 339..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..608
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1036 AA; 114819 MW; 4438E14C14357E89 CRC64;
MQLRTVLDVN VVDVQKRRNP SKHYVYLISV TYSDSTSHVI YRRYSKFFDL QMRILDQFPI
EGGQKDPKKR IIPFLPGKVL FRRSHIRDVA VRRLKHLDNY CKALLKLPVN ISQSEEVLKF
FETKSEDLNP PTEDCGSSGK RKSGLDASDP MLLEQYVVVA NYEKQEPAEI SLQAGEVVDV
IEKSESGWWF VSTAEEQGWV PATYLNSHSG TRDDLELGAS KVGEEEKYIT VQSYSGQGKD
EIAFEKGVIV EVIQKNLEGW WFVRYQDKEG WAPASYLKKM KDDFSPRKKT VTGPVEIIGN
IMEISNLLNK KASSEKDMQS ECVPESPQVS KKEISLPIPC AESSPVNSPQ DGKSKPEPAS
PAIARIAPHR VEIGSPILRQ KPPPRRDATL GFQLPSPPEP PTVEAEYYTI ADFQSCISDG
ISFNGGQKAD VIEKNSGGWW YVQIGEKEGW APCSFIDKRK KPNLNRRTST LCRPKVPPPA
PPVKKQDSAE SAPPSSPGSE APESPGSSGR PVYEEPEYDV PAIGDLDLES EFEFLRGGSS
LVVGKNEDTS SEKGSHLSSK PSPASSLHSA SFKLGESFED GHEAEVEEEC IYENDCFRPR
DTPERQCSRD SNSFKTSGLS DSGKTANPTS AGWRSPGNKL KIDLNGSPFS IKAEESSSPK
SGSGESATDV SRSHKDQDES KASSPPKSAF KLKPVVRPKP QLNKASSAEK MDISTLRRQL
RPTGQLKNGT KTKGSRGDSD LEGSVYRTTD PYEKVQESEV SFPAGVEVEV LEKQESGWWY
IRWGDNEGWA PTYFLEPARQ QEDIAGSESD ETTIKLGSLS KSNSLEKNEQ RVQVLNNINQ
NMKKVTPPIP SKPPGGLSKP SSLFDSRKQN NTKQQQVVRP QSVFISAPIK DGPSPVGSLR
RNESLNSTDH PRASPTVRRN ASFGTVPRST VTNNIVLPNK NRSGTGSSES IGQSSPKNAL
PVSTVRPKPH IIHNNLREVY VSIADYHGDE ETMGFPEGTS LEVLEKNPNG WWYCKVLDNG
RPRKGWVPSN YLEKRH
//