ID A0A3P8WJD0_CYNSE Unreviewed; 1994 AA.
AC A0A3P8WJD0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Rho GTPase activating protein 32 {ECO:0000313|Ensembl:ENSCSEP00000027558.1};
GN Name=ARHGAP32 {ECO:0000313|Ensembl:ENSCSEP00000027558.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000027558.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000027558.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000027558.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PX domain-containing GAP family.
CC {ECO:0000256|ARBA:ARBA00008795}.
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DR RefSeq; XP_008330709.1; XM_008332487.2.
DR RefSeq; XP_016897262.1; XM_017041773.1.
DR STRING; 244447.ENSCSEP00000027558; -.
DR Ensembl; ENSCSET00000027927.1; ENSCSEP00000027558.1; ENSCSEG00000017589.1.
DR GeneID; 103394975; -.
DR KEGG; csem:103394975; -.
DR CTD; 569434; -.
DR GeneTree; ENSGT00940000154313; -.
DR InParanoid; A0A3P8WJD0; -.
DR OrthoDB; 5314555at2759; -.
DR Proteomes; UP000265120; Chromosome 19.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR CDD; cd11835; SH3_ARHGAP32_33; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF13; RHO GTPASE-ACTIVATING PROTEIN 32; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 252..314
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 407..602
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 945..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1003..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1789..1957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1029
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1066
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1079..1111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1258..1273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1791..1815
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1822..1845
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1879..1899
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1994 AA; 219552 MW; D5CC99242BF1392B CRC64;
MEAGSGAAAA VGSAALGLLG STATSSHDIL DRGLRPGRHL DDDDILPELA HIHPRERPDW
EETISAMARS AEIPELRSEP LMRSSSSSTA SMKVKNVKKL CFTKGHFPKL AECAHFHYEN
VDFGSIQLSL GDEQCEVTRN GYESKEPVYL VHIYCQGRSW IVKRSYEDFR VLDKHLHLCI
YDRRFSQLSE LPRLESLNDQ SESVSQMLLA YLSRLSAIAD NKINCGPALT WMEVDNKGNH
LLVHEESSIN VPAIAAAHVI KRYIAQASDE LSFEVGDIVS VIDMPPKEDT TWWRGKHGFQ
VGFFPSECVE LINDKVPQSM TNSVPKPATP SSGLQPASWS LFPPYLEMES VIEDSTWVAD
PLNHYSISSV SKKHGKLITF LRSFMKSRPT KQKLKQRGIL RERVFGCDLG EHLLNSGHDV
PQVLKSCTEF IEKHGVVDGI YRLSGIASNI QKLRHEFDSE QIPDLTKDVY IQDIHCVGSL
CKLYFRELPN PLLTYQLYEK FSEAVSAATD EERLIKIHDV IQQLPPPHYR TLEFLMRHLS
RLAAFSYITN MHSKNLAIVW APNLLRSKQI ESACFSGTAA FMEVRIQSVV VEFILNHVDV
LFSTKLSSLI REGAGLNSLS RPKSLLVSSP STKLLSLEEA QARTQAQINS PVTEDSKYIE
VGEGPAALQG KFHTVIEFPT ERKRPPIKSK KSPVGSWRSF FNLGKSSSMS KRKLHRNPSE
PNELKAMALA GGRGETATLR SAKSEESLSS LHNVEGEAKV YRPRRPRSSS DALSASFNGE
LLDSRQHCNS YDNLDATEES DGDDGPICVP ALISPPRSAG EDVDLSPPDI GMASLDFDPM
SFQCSLPDTS YAFPVDDSIS GAEASTLKRS PGSICGKTNG PGVSTSFLGC LTSPVLSTTF
ISAAGENMEN KKLPTSHSYS DKPTQAVSPI KCSKAISMTP FPTSELFTTE MPDKSKGGQA
VAAPSLAPPA IPKDSSNPTG SVLLRPKERP LSEAFQMELQ SKLTAFESTE SQERTVEESV
QQTPAASHQD LQGVVAADTS KDPTPYSLSA TAPTSAPPPP APPPKNAARM LALALAESAQ
QVCLQSQSRS SEPSTPNLQS QDTSEDLTPA LAPQVTASCE ERAEQTCPPL PQPPPTTATA
VIMASSIQLH QVHLTSTSNP TTKQQQQPVE VTGTVTKTME SATSLRSPPE THPPIEFPSH
DTPLLKCPPL PTTINPTSPT RTSPERLQIL TGPVHTSSTP APIQSGSGKV IPQPGSEVKS
DNKASQSITK PLEQPPPIAQ KPKNLAIPPP QTQTQTQLQP HLPTPPQPQT PTNLQIQTQA
LPKPPTLSKA SARVAPTSAE PLEKPREAIK PVQPCTESSK YHDSYTPKPP APPVRTIESK
RATAALSQTE AAYHAVDEGL APGHIEDALP QRPLSPPHKS SMHQQAYLYH PKGEPVLVES
PGAPYYHQRP VTLGPPPMTH HYRPDDVPPY LSYVSKSEPQ IPYSARMDNR YSTLGPRSYH
HSMKSRGNSR GMFVSAGPGH PGYSHDRNQG YPTIRRVHSL HVPSAVRSVP IQRTEVPPDD
DMFFYRPMYQ CKAYPQSPQQ PPQQSSQGDY HVTQLQPYFE NGRVQYRYSP YSGSVHLEAP
FCDMDPYATI RIRHFHPHGS RDPGAVSGRS SGKAAGYHYL ARHILPPGKE HSFVSRDMPP
NHGTKESAAY LSWDPEESER LRMHSIRRES RARQRIKGPV LSQYDNVGLY TPADISGYET
LHLRSKSDPG KAVLLVAESK DGRYLPRHMV SDPDVLMYLE TDKHVQGCDK SDGLSKQSSS
KKCHSSHSPP ATLSHSLSHP EGGRYESGEE KLTADGSRPK HWQQECPNKR NIQPRYECPD
SDHPQSKGRA SSSYHNTDDH ASVAREQVSR SKPERSHSVR EQPQYSQSKD MDRDYSYQKH
NTKTTTQSHY DNLDDYHPVP QAQAPVQKHG SSSFPAPGFS GSHSNRAYST ALGQGAFIQT
ELAMPRPETE ICTE
//
