ID A0A3P8WLM1_CYNSE Unreviewed; 193 AA.
AC A0A3P8WLM1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Glycoprotein hormone beta-5-like {ECO:0000313|Ensembl:ENSCSEP00000026411.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000026411.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000026411.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000026411.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000256|ARBA:ARBA00006552}.
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DR AlphaFoldDB; A0A3P8WLM1; -.
DR STRING; 244447.ENSCSEP00000026411; -.
DR Ensembl; ENSCSET00000026764.1; ENSCSEP00000026411.1; ENSCSEG00000016879.1.
DR GeneTree; ENSGT00730000111179; -.
DR InParanoid; A0A3P8WLM1; -.
DR Proteomes; UP000265120; Chromosome 1.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR PANTHER; PTHR11515; GLYCOPROTEIN HORMONE BETA CHAIN; 1.
DR PANTHER; PTHR11515:SF14; GLYCOPROTEIN HORMONE BETA-5; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 98..191
FT /note="Glycoprotein hormone subunit beta"
FT /evidence="ECO:0000259|Pfam:PF00007"
SQ SEQUENCE 193 AA; 21867 MW; 308DC0F0C70DCEE3 CRC64;
MQFQNILPKR RNCAVSSDIS PLVNTAGEMK ETGCINKLHR RCLIPNYCTS RNSSAVKQLF
LNFSMHFQLP PLPFLILLVA KVAVICSAVS TTLHGFRGCA VREFSFVAQK PGCKGLRITT
EACWGRCHTW EKPVPEPPYI QRHHRVCTYS RIRHMTARLP GCQPNISSLY HYPMALHCHC
AICSTQDTEC ETF
//
