ID A0A3P8WMK2_CYNSE Unreviewed; 872 AA.
AC A0A3P8WMK2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Retinoblastoma 1 {ECO:0000313|Ensembl:ENSCSEP00000028678.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000028678.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000028678.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000028678.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR AlphaFoldDB; A0A3P8WMK2; -.
DR STRING; 244447.ENSCSEP00000028678; -.
DR Ensembl; ENSCSET00000029067.1; ENSCSEP00000028678.1; ENSCSEG00000018076.1.
DR GeneTree; ENSGT00950000183202; -.
DR InParanoid; A0A3P8WMK2; -.
DR Proteomes; UP000265120; Chromosome 19.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051172; P:negative regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20599; CYCLIN_RB; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 6.10.140.1380; -; 1.
DR Gene3D; 6.10.250.530; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF17; RETINOBLASTOMA-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR Pfam; PF08934; Rb_C; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 73..191
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 337..524
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 721..872
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 872 AA; 98697 MW; 9E0B71471F961C29 CRC64;
MPPKKRNSGS TQSKGLKPSA ENAQADKGSP EHGDKDAAFL NLCKSLQVTD LVCDRAWALW
KSVQESTNEA STSLWGGCLF VTVTDLDVSC FTLTQVLKAV SLNVKDFLSV VRKMDVNLDT
ITTKVNAAMT RLEKKYDVTL ALYQRFEKER ETMRSCWTMF LLAKGRVLQM EDDLVIAFQL
LLCTLEFFIK RCPVSLLQPP YSKMEHSLTD PPTRTSRRYQ GKAKSIRPPE PEVDVQLLET
LCKENDCNAE EVKNVYQNSF SAFLDSLDLS RSSDVPQSND LDKQYEELYL RSRDIDGRLF
FDEDPTVLLP KVEILQVERT PKKNLPDEDG VIIPPQTPIR AAMTSIQQLR GDLISTGDTP
STTLTTYFKN CTVDPTQGVL KRLEMLDQRF SQRFGQAVGP RCVLLGNQRF TLGVRLYYKV
MEAMLKSEEK RLSVQNFSKL LNDSTFHTSL LACALEVVMA TYGGEKLHKI PAKKKTTCSC
VQPPWSRAFP QDLAFCLTTN LRAHATSESL RLFKQGGSPL FELLKQEHEG GAAEQAETTA
SFNQPLQHNH TAADLYLSPV RPGHRVAPPE SPATPNSHAS SQAANQPTNQ TPRHIKSNSL
SLFYKKLYRL AYIRLKLLCS YLLSSHPELE PIIWTLFQHT LQHEYELMRD RHLDQLMMSA
MYAICKVKSV DLRFKTIVTA YKNMPNANQE TFKHVLISEG HYDSIIVFYN QVFMQKLKTN
ILQYASPRPP PLSPIPQIPR SPYKFQNSPL RVPGSNNVYI SPLKSPRMSP GIMTPRSRML
VSIGESFGHS SRFQKINQMV NSSERSFKRT LDMGSIPKPL KRLRFDGDGQ DEADGSKSNG
DSTLILKLVE MSSTRSRMQE QKLKEDADSR KE
//
