ID A0A3P8WP90_CYNSE Unreviewed; 640 AA.
AC A0A3P8WP90;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Carnitine O-acetyltransferase {ECO:0000313|Ensembl:ENSCSEP00000028297.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000028297.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000028297.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000028297.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR RefSeq; XP_008322671.1; XM_008324449.2.
DR AlphaFoldDB; A0A3P8WP90; -.
DR STRING; 244447.ENSCSEP00000028297; -.
DR Ensembl; ENSCSET00000028675.1; ENSCSEP00000028297.1; ENSCSEG00000018060.1.
DR GeneID; 103389153; -.
DR KEGG; csem:103389153; -.
DR CTD; 449545; -.
DR GeneTree; ENSGT01060000248556; -.
DR InParanoid; A0A3P8WP90; -.
DR OMA; TTQHRDT; -.
DR OrthoDB; 1429709at2759; -.
DR Proteomes; UP000265120; Chromosome 14.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589:SF50; CARNITINE O-ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801}.
FT DOMAIN 49..622
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 354
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
FT BINDING 433
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-2"
FT BINDING 437..444
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-2"
FT BINDING 466
FT /ligand="(R)-carnitine"
FT /ligand_id="ChEBI:CHEBI:16347"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-2"
FT BINDING 468
FT /ligand="(R)-carnitine"
FT /ligand_id="ChEBI:CHEBI:16347"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-2"
FT BINDING 470
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-2"
FT BINDING 479
FT /ligand="(R)-carnitine"
FT /ligand_id="ChEBI:CHEBI:16347"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-2"
FT BINDING 518
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-2"
FT BINDING 569
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-2"
SQ SEQUENCE 640 AA; 71871 MW; 18652731860FDB77 CRC64;
MWGICSRTAV KLGMAKPCSL VKTNHLVKPV SATRVAGRYL THQQGLPCLP VPPLQQTCER
YITALEPIVE VDELKHTKEL VQEFQKSGGV GEKLQKGLEE RAKSTENWLS EWWVQLAYLE
YRLPVVVHSS PGLVLPRMNF RDKQGQIRFA AKLIAGVLDF KTMIDNETLP VEYLGGKALC
MNQYYEVLSS CRVPGLKRDM VVNHAKSTPP PKHIIVVHNF QFFALDVYNA DDSPLTVEQL
CSQLERICSS SNQNMVEPVG ILTTQHRDAW GQAYVNLIKD ATNKASVSTI QRSIFTLCMD
GVMPQESEQT YRSSAAIQML HGGGSRWNSA NRWFDKTLQF IVGEDGTCGA NYEHAPAEGP
PIVALIDHVV EYTRKEKDEE VLQPPEEPLP GPQKLHFNIT PEVKKSIEEA KQSMNTLAQD
LDMKVIVFEH FGKNVPKVHK MSPDAFIQMA LQLAYYRLYQ RCCATYESAS LRMFRLGRTD
TIRSASNASA AFIRAFDDSS RQNTEKLELM EKAVHAHRSY TNMAINGQAI DRHLLGLRMQ
AVEEKLTVPE IFKDAAYAKA LHYQLSTSQV PSKTDCVMCF GPVVQNGYGV CYNPMNDHIN
FALSSFNTCK ETNSAHLAQA VESALLDMRA LLEQTPRAKL
//
