ID A0A3P8WPX1_CYNSE Unreviewed; 827 AA.
AC A0A3P8WPX1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Retinoblastoma 1 {ECO:0000313|Ensembl:ENSCSEP00000028769.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000028769.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000028769.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000028769.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR AlphaFoldDB; A0A3P8WPX1; -.
DR Ensembl; ENSCSET00000029161.1; ENSCSEP00000028769.1; ENSCSEG00000018076.1.
DR GeneTree; ENSGT00950000183202; -.
DR Proteomes; UP000265120; Chromosome 19.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051172; P:negative regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20599; CYCLIN_RB; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 6.10.140.1380; -; 1.
DR Gene3D; 6.10.250.530; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF17; RETINOBLASTOMA-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR Pfam; PF08934; Rb_C; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 81..193
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 339..481
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 690..827
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..827
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 93846 MW; CDB154EA5711CEA8 CRC64;
MPPKKRNSGS TQSKGLKPSA ENAQADKGSP ELSVKKHGDK DAAFLNLCKS LQVTDLVCDR
AWALWKSVQE STNEALWGGC LFVTVTDLDV SCFTLTQVLK AVSLNVKDFL SVVRKMDVNL
DTITTKVNAA MTRLEKKYDV TLALYQRFEK ERETMRSCWT MFLLAKGRVL QMEDDLVIAF
QLLLCTLEFF IKRCPVSLLQ PPYKSAITKV QSPPTRTSRR YQGKAKSIRP PEPEVDVQLL
ETLCKENDCN AEEVKNVYQN SFSAFLDSLD LSRSSDVPQS NDLDKQYEEL YLRSRDIDGR
LFFDEDPTVL LPKVEILQVE RTPKKNLPDE DGVIIPPQTP IRAAMTSIQQ LRGDLISTGD
TPSTTLTTYF KNCTVDPTQG VLKRLEMLDQ RFSQRFGQAV GPRCVLLGNQ RFTLGVRLYY
KVMEAMLKSE EKRLSVQNFS KLLNDSTFHT SLLACALEVV MATYGGEHLH SHPLSCLLPH
THTHTHTPTR TESLCKHLKC SAEQAETTAS FNQPLQHNHT AADLYLSPVR PGHRVAPPES
PATPNSHASS QAANQPTNQT PRHIKSNSLS LFYKKLYRLA YIRLKLLCSY LLSSHPELEP
IIWTLFQHTL QHEYELMRDR HLDQLMMSAM YAICKVKSVD LRFKTIVTAY KNMPNANQET
FKHVLISEGH YDSIIVFYNQ VFMQKLKTNI LQYASPRPPP LSPIPQIPRS PYKFQNSPLR
VPGSNNVYIS PLKSPRMSPG IMTPRSRMLV SIGESFGHSS RFQKINQMVN SSERSFKRTL
DMGSIPKPLK RLRFDGDGQD EADGRCGSTR SRMQEQKLKE DADSRKE
//
