ID   A0A3P8WPY2_CYNSE        Unreviewed;       767 AA.
AC   A0A3P8WPY2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=FCH and mu domain containing endocytic adaptor 1 {ECO:0000313|Ensembl:ENSCSEP00000026765.1};
GN   Name=FCHO1 {ECO:0000313|Ensembl:ENSCSEP00000026765.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000026765.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000026765.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000026765.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC       {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004283}.
CC   -!- SIMILARITY: Belongs to the FCHO family.
CC       {ECO:0000256|ARBA:ARBA00011064}.
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DR   AlphaFoldDB; A0A3P8WPY2; -.
DR   STRING; 244447.ENSCSEP00000026765; -.
DR   Ensembl; ENSCSET00000027122.1; ENSCSEP00000026765.1; ENSCSEG00000017008.1.
DR   GeneTree; ENSGT00940000160489; -.
DR   InParanoid; A0A3P8WPY2; -.
DR   OMA; ENYQSKC; -.
DR   Proteomes; UP000265120; Chromosome 2.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR028565; MHD.
DR   InterPro; IPR018808; Muniscin_C.
DR   PANTHER; PTHR23065:SF6; F-BAR DOMAIN ONLY PROTEIN 1; 1.
DR   PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF10291; muHD; 1.
DR   SMART; SM00055; FCH; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT   DOMAIN          13..262
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          519..764
FT                   /note="MHD"
FT                   /evidence="ECO:0000259|PROSITE:PS51072"
FT   REGION          489..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   767 AA;  85121 MW;  C7BE93F350366C54 CRC64;
     MLVNCSRLDA NSVFVCACAV SLQGEKNAGF DVLYHNMKHG QLATKELAEF VRERVAIEET
     YSKSMSKLAK IASNGSPQGT FAPMWDVFRV SSDKLALCHL ELMRKMNDLI RDINKYGDEQ
     VKIHRKTKEE MVGTVEAVQA LQVQSGHLQK SKESYHAKCL ELDRLRKDGA PQKELEKAEL
     KSKKAAESFA LCIEKYNRVG GEFEQKMSES AQTFQDIEES HLRQMKQLIK GYSHPIEDTH
     VQVGQVHEEF KQNVENIGID NLIQKFAEQK GTGKDRPALA GFEEYMTALA PEGVKKSRAK
     AFRLPGLGRK DKEPDFTCVV VCPFMQNSPL EVDDEGFVVR ADSTQNDILS HKENNFYSSD
     SDFDDEEPKK FHIQIRPVAT SSRSNLANTD KELKATVGVL SLPPNRGVRQ QPSSPFSSLV
     FVVFRLSSTV SGSDSLFGPP LESAFKSKSF DGREQLRDHS FAASECKSDK YIFFFFKLSR
     SLCSSPLPEP SPSLTSSSSS SPMHVSRGPS PISLSTQEAW PVAAAITEYV NAYFKGGQHN
     RSVCLSVCVD LMLTLGQTSR LLCVNPTPPL LHSDPSQSDP DTRDFWFNMQ ALQVYLQREA
     ELNPQASYYN IGLIKYQVSS QDPGRAPLLL SAECQRSGTV TRVSLDYHCC PATAPSTQLT
     AVQVLLPLDH TATDLQCQPP ATWNTEERRL LWKLSNLSPT NHSSGTLCAS WQCLEVPRGP
     PPSLAVQFVG SGASLSGMDV ELVGSRYRMS LVKKRFATGK YMAGCSL
//