ID A0A3P8WR26_CYNSE Unreviewed; 3596 AA.
AC A0A3P8WR26;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=[Histone H3]-lysine(4) N-trimethyltransferase {ECO:0008006|Google:ProtNLM};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000028932.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000028932.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000028932.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR Ensembl; ENSCSET00000029327.1; ENSCSEP00000028932.1; ENSCSEG00000018510.1.
DR GeneTree; ENSGT00940000155281; -.
DR Proteomes; UP000265120; Chromosome 3.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd22026; HMG-box_KMT2C; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 6.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR PANTHER; PTHR45888:SF6; HL01030P-RELATED; 1.
DR Pfam; PF00628; PHD; 3.
DR SMART; SM00249; PHD; 7.
DR SMART; SM00184; RING; 5.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 5.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 5.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 468..574
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 579..631
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 628..678
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2815..2868
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2865..2915
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2942..2997
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1298..1353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1376..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1469..1515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1572..1685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1746..1782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1826..1938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1953..1979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2055..2123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2150..2263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2276..2770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3077..3141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3377..3399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3524..3596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3173..3200
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 56..70
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..175
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..216
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..243
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1323..1353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1479..1515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1572..1613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1626..1673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1826..1850
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1865..1879
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1880..1905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1906..1929
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1961..1979
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2055..2104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2150..2174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2185..2263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2284..2332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2333..2387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2389..2437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2438..2462
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2470..2505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2546..2573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2614..2640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2665..2680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2681..2700
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3084..3129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3543..3596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3596 AA; 387410 MW; 86FB79E43A35998D CRC64;
MPSEAQSQEP RNRGPPPPVT RAGRSAQLAK AAATCSINDR RPRGRPRKDG SGGRSKSPVP
PPPPPPPSAS KSRKKGRSRG RAQVEDEESM DTMENKLPPK TEVKEKTTGY RRSTSRRKSS
TNPDLDPDPE PDPDPEPDPD PDPEPDPDPD PDPEPDPGPD PEPEPEPDPV PESEPEPEPE
PGPGPGPVPV PEPEPETYPD PDPISNPIPT PLSEPETDPQ PSQDRLSPEP QPNPDPPPPD
PTVTECAIKL DPNAEVDSGP SSSPVSSPGP GPSQVKEEEE EEVNLVIHSL GHSPSSNLQP
PPDSVNKEED DASTTTHNTA PTDNCSPSKE PTKTEGDVAR PMAHSPTLSP CHSLPVSPCP
QLEDEDSLSP LFLRSLSDDS ASSPTPSLSH AHKRLQQCAF CYRGNDPPLG QGHLLVFGPT
PGYIPLHILN RRTSSDRDSD CHDHCYQGSE APPLPSTPEQ CESSSEFVEQ LGLIGLPHDV
NVQSLFDPTG QCCAHLQCAA WSEGVCLGEG QSLLYVDKAI DLGSTQVCAF CHRLGASLRC
RQAGCGWSYH FPCAAASGAH QDWNQRRILC TRHSDTASSA QCTSCSGTGD VSSLLMCCCC
GSHYHSTCLD PPLHPSPLRR VGWQCPECRV CQICRLGGDK GVLLTCECCD KAFHALCLTP
SLDQVLTSGW SCKNCRVCRR CGVRSSGQWA NHPFLCESCD LALPCPLCGH TAGLYGPQEY
LTCTCCYRCV HTECIVQSGE GRAGSETYIC STCRTQEEDV IPRSPTQNSP TCLHLVPLKS
LSPNILQPPD NSHTENPPIS SIPPQSLKVA LMDMSEVEKI NEPTHTNLPE PQRSSTSSPI
NSLESKSPGS VHPEIQETPA QDNLSELSRS QEAVDSYPPE LQQTCAPASP NLSEVPKSPD
SFVPDSTDLQ HPPIPLNESE VFDSPQPIQP DLTNSPKSNL SEVSENPKPI ELDSAELHHT
SSGPNSDTVE EQKAPEALHP DPLEIKQYPT LPHPNSEVQQ SSPPSDFDPS DVEKGPELVC
HDSTALQTST TPTHPGLQQY SEPAQPDLSD FQHQTSTNSD PLNCSPTDSI SLELPLSSVT
VHSDSTDLQV SSESTQSDPV EPQQSPKPAN PDSPEMELNL EPLQHKTLAA EPTDSEPSDV
QKCPKSDHSD FSFTKDPALS QPSSPQLQED QSSIHHHASN LQRTHPANPS PLKLKQGPTS
PQSPPPDIQQ ISAFSNPDPV KIQLIKSLET ENDDPSDIEV SHEIGQHGPE SLKPTHSEQS
HLICKDYSEP QCSPLEIETP ACEVQHEILP LKQNPAELQE LFQGGPTELQ GSPKLEDRPT
PSPPIAKSSS TQCLSGSTDL FKTELSPSSP VELQQSPTHM ILTQASNSLT HNFSEEHLTA
KQPQPNSPLP CGLAQSPAED TTAQTQSENS GISSVVILMQ SPTKPHYDAP CNMTFSPACP
GISSSQSPIQ NDKSTLDHKT SGFASSVHLH HETEQDTSTL DQDTLPVCHG STQTKRRHTS
APCSPVQSRL RPTPACSLSL PGSPVQVDST QHLRPLLLSP IASYLTEQST LTGESSENSN
VELLSVKVSS AQLSPNKDAQ TLESNPTFEN PTMHHNMDAQ LSHQSSMISP EPSSPCSILP
VPPPESLLHT STSVEHSSLT LSPSADKVEE TSSPSSHIHQ TPLNDTHSGS MEAKADPQPQ
PGLGDINLTH TNEIPVCPTL QANSSTICSA SSINPNLPET VISADSPLCQ DEEMQAAVNT
LAVNPETKDE SCNPEPLSVS PLFNDTQTSP VSKEGNGDSL HADTHLAQSP VASCPSSPMH
PCLSSPKHPS NLQQICQSPP VICPSSPPNP SPSSLPDPCL STPTNPCPSS PLNPLSSSSS
KPCPLSPSDP CPPSPSNICL RSPSNPCPQS SSNSCPQSPS HSCPESPSNL GPPSPTNPNP
CPESPSNPCS ESPSNPCVSS PLILCPSSPT HHCPLSPAHS SPSSPTHPCP PSPPQPCPSS
PPLPCSTNYP YVEPSSPLLV TVAGFSPSHC SLTDPSPNRS SVSHNLSNIA SESCVHPDPN
SAILTGDSIL HVSPRSSPAG QASPVHITST GVHLSRKSSS LTNSPHSSSA HTPVIGSPPC
SPTQAVESPA DEPHYSSAND TGTIFGHTVT QTSYPLPISA TQSTLFTGEV TLSPSHESPD
PFSSDANSNL DRLSQPPVCP EMKHNESSAS VSLSNQRPSS PANPTATQPA SPGSSLSSDQ
DNTVVPGSSH SPHPAFVDSQ VSPVQTQSVN RTKVESPVHA SDSVLIQTSA ISGLHKPALS
KESHVSDSEA SPSSEQCENH TITDLNPENV DKSVSSATET RARSPATEDM DQTSILSKEE
DDLEKSNCEG KNESEASNQA REVKKFEVHL IEKVQPEDGE PVVRTEGLQD KEQVSSLGVD
TSLLSEDPRM SPSTPLHLQQ SSSSPLPQKQ TPSPSSPQHS MPQSPFPQSS PPSAPLGSSL
PPSPLPTEGD FEEASSSSFS CPKTPLTPSR SNCSPHPSTS PLRNRILETE PIAHPEGPVL
ETGEKEEPDN TIIAAQLQSQ LESSATELAK DEHQSLTEKS KEATENLQVR EGVDDEEGEN
EEDASQEDQL VLVGKEEESL SPVLDMDSTF DKEVMDLMTS SSPPPSLLNL SPNSSPPFSR
REKSRPLRAT PPWSSRPVDD LSIRLRQSPF STEASPETSP NRVPVTPPPL SPPSPPSSRE
SPNLKVPSSV TVFPLTPKIG MGKPAISKRK FSPGRSRVKQ SRGTGFPGRR RSRGGGIGGG
RGGGRGRSRL KTQDCVPVSP GCAYVEVFQP KEEEENSMHN TVVMFSTSDH FTLRQDMCVV
CGSFGQGPEG RLLACSQCGQ CYHPYCVNVK ITRVVLTKGW RCLECTVCEA CGEASDPARL
LLCDDCDISY HTYCLDPPLH TVPKGAWKCK WCVCCIQCGS TSPGLNCEWM NNYSRCGPCA
SLSRCPLCHR EYTHDDLILQ CQQCDRWVHS VCQGLSSEQE VEVAADEGFD CTLCRTHSRV
PYIRPETSES PFRAQIISRM READPKTYTQ DGVCLTESGL SHLQSLVEPL TSPRRYRRCK
PKLKLRIINQ NSVSVLQTPE PDLSTEHDIG RGELDCEMKS DSSPERDHVP DDDVIKEAEA
PDGKKKRKPY RPGIGGFMVR QRGGKIGPTR FKLWRKDSTE MLPARDEDTE ITDQAMEKVK
KRYRKKKTKL EEEFPSYLQE AFFCRDLLDR SRLVEKKVSA ETTSGSQLSA PMGLIKTSTT
AVHGPSPSGL VSMVANRKQG TLPVSEDLVD LSDVLSSDPH ILATGHTGQF HVERSPSPFA
GLDISSMADD SSLTCEPTGA CGRGQRAVQE ESLDAILSPE LDKMVTDGAI LSKLSKIPEL
EGKDVEEVFT AVMSPNSISN QSQHSHHTHA AAGCKTHTQQ PGVTYPRLPL ANGLIGATAQ
LSNTHGTIQG SLAYRALGVP PSPPTCSNMV TASANQPSAG EGEQDMMSAA QRGMLKWEKE
EVLGEMATVA PVLYCNTNFP QLREQYPEWT TRVKQIAKLW RKASSQDRAP YVQKARDNRA
AQRINKVTLS NDPLKRHLQQ PQQQLQQQQQ QQQQQQQQQQ QQQQQQQQQQ QPQQQQ
//
