ID A0A3P8WRA7_CYNSE Unreviewed; 871 AA.
AC A0A3P8WRA7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Complement component C7 {ECO:0000313|Ensembl:ENSCSEP00000027180.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000027180.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000027180.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000027180.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; A0A3P8WRA7; -.
DR STRING; 244447.ENSCSEP00000027180; -.
DR Ensembl; ENSCSET00000027546.1; ENSCSEP00000027180.1; ENSCSEG00000017370.1.
DR GeneTree; ENSGT00940000156804; -.
DR InParanoid; A0A3P8WRA7; -.
DR Proteomes; UP000265120; Chromosome Z.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR048825; C7_KAZAL.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR040729; Kazal_3.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF2; COMPLEMENT COMPONENT C7; 1.
DR Pfam; PF21330; C7_KAZAL; 1.
DR Pfam; PF18434; Kazal_3; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00084; Sushi; 2.
DR Pfam; PF00090; TSP_1; 2.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50092; TSP1; 2.
PE 3: Inferred from homology;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 40..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 158..482
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 595..653
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 654..717
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 127..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 871 AA; 97202 MW; 61DED0056C728D8C CRC64;
MHLYVFWHSL VSSLLYSLFP VSFHLLFLLT SLSPIQSMTL WFLAVFPCLL LFSHQGLCVQ
RINCQWGPYG DWSQCDGCTK LQTRSRPMAV YAQFGGNPCN GGRTETRACE TKQGCPLEDG
CGNRFRCLSG KCISMSQVCN GDQDCEEDGL DERQCDDKFI TCAVSQPPPN IEHLGLGYDA
VSGKQRGIVI NTKSFGGQCH LLNSGVHNTV FRLPLSIIKY QTMVTVQNDI SDEMFTSTWH
YAKDTVSRET VTGTTKGYRN YDFHQTIEEI KHHNLLVLKN SIDVTHFQSN SPNSIPLSEE
FWKALTRLPS VYDYAAYRKV IERFGTHYVS EGSLGGSFKV VASIDEETKK ETKTETLDHQ
ERTRTKRWVL IFPVYHTSYK KDQYSRPVNR EHFQRSQIKK VDVEGGGVEH IEALKTMNIN
NAERNWEMYS NWADSLRSFP QVTKQKIRPL SELVKEVQCA GVKKLYLQKA IDQYLAESDS
CHCRPCSNNG MTIMDRDECK CICKPGTLGL GCEQGTEAEG QPGVIQGSWS CWSGWSSCSG
NKRSRSRSCS NPSPQNGGQF CIGEASETSD CEDQELQYLR TMEPQCFDFT LPPSQHCGAP
PALVNGYVLD PKDIYLVGSR VEYTCTPGLY LIGEPLECKA DLTWSAKPGL CTTSSCKIDA
LAEGVRAYPK KEFYHLGETV SFSCSPGHEL KGEKEVTCEA GLYLRFSADP KFFRCVEVAP
PTASSVQCEP WQKVSKGKCV CKMPFECGSS LELCVNLNRD GIPSRVINVC KMHALQCLGG
NITIAEDSTC TWPPRNDVHC NSCDMWETCD AQTNRCRCKD SANCTTPGTN VCVRVGNDIT
AAGQTMSECE AGFKRCKGEK VTVLSLLPCT S
//
