ID A0A3P8WRH3_CYNSE Unreviewed; 412 AA.
AC A0A3P8WRH3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Cytoplasmic protein {ECO:0000256|PIRNR:PIRNR037874};
GN Name=NCK1 {ECO:0000313|Ensembl:ENSCSEP00000028096.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000028096.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000028096.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000028096.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037874}.
CC Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874}.
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DR AlphaFoldDB; A0A3P8WRH3; -.
DR STRING; 244447.ENSCSEP00000028096; -.
DR Ensembl; ENSCSET00000028471.1; ENSCSEP00000028096.1; ENSCSEG00000017949.1.
DR GeneTree; ENSGT00940000156601; -.
DR InParanoid; A0A3P8WRH3; -.
DR OMA; ADTDMST; -.
DR Proteomes; UP000265120; Chromosome 3.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:UniProtKB-UniRule.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd11900; SH3_Nck1_1; 1.
DR CDD; cd11901; SH3_Nck1_2; 1.
DR CDD; cd11904; SH3_Nck1_3; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR017304; NCK.
DR InterPro; IPR035562; Nck1_SH3_1.
DR InterPro; IPR035564; Nck1_SH3_2.
DR InterPro; IPR035565; Nck1_SH3_3.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR19969:SF16; CYTOPLASMIC PROTEIN NCK1; 1.
DR PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR PIRSF; PIRSF037874; Cytoplasmic_NCK; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037874};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR037874};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Translation regulation {ECO:0000256|PIRNR:PIRNR037874}.
FT DOMAIN 23..82
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 129..188
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 220..282
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 315..409
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 412 AA; 46236 MW; 2F2DC2F84812261C CRC64;
MRSTETLTAL QVLSFDAVQF KMTEEVIVIA KFDYMAQQDQ ELDIKKNERL WLLDDSKSWW
RVRNATNKTG FVPSNYVERK NSARKASIVK NLKDTLGFSR VKSRKGPMRD TASNVDADMY
ADNGERLYDL NLPALVKFSY TAEREDELSL VKGTRVVVME KCSDGWWRGS YNGRSGWFPS
NYVTEDMDGT AGGGGMGGDP VTSLTEKLAA VVNSTTNGNR VLHTVQALYP FSSGNDEELN
FERGEVMEVV EKPENDPEWW KCRKADGQLG LVPKNYVTVL DSSSHKPSAG LAGPPTPDCD
YISPSGSGRF AGKEWYYGKV TRHQAEVALN QRGTEGDFLI RDSESSPNDF SISLKAQSKN
KHFKVQLKEN LYCIGQRKFN SMEELVEHYK KAPIFTSEQG DKLYLIKALA AS
//
