ID A0A3P8WRL9_CYNSE Unreviewed; 1689 AA.
AC A0A3P8WRL9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Neurexin-3b {ECO:0000313|Ensembl:ENSCSEP00000029414.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000029414.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000029414.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000029414.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSCSET00000029814.1; ENSCSEP00000029414.1; ENSCSEG00000018780.1.
DR GeneTree; ENSGT00940000167343; -.
DR Proteomes; UP000265120; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF48; NEUREXIN-3B; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1689
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018207806"
FT TRANSMEM 1612..1632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..203
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 194..231
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 253..435
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 442..634
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 638..675
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 680..852
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 869..1041
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1044..1081
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1085..1284
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1316..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1498..1548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1653..1689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1425..1442
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1516..1531
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1689 AA; 184939 MW; 5A39AE237A3D49B4 CRC64;
MNSSSLPSPI LLLLSTFLCL SGGLEFTGSE GQWARYLRWD ASTKSDLTFQ FKTSQSKGLL
LYFDDGGFCD FLLLSIAAGK LQLIVSIDCA EMTITSHKLV NDSRWHFAAI NRHYLQTGLA
LDGQTQMEEV RPQRQYMKIV SDLFLGGLPG DIRPSAITLP SVLELPPFKG IITDLSYGSK
LPTLINSQKV RLEMMGLCTE NPCENGGICS LADGETYCDC SKTGYVGRYC TEAVQKIPGL
AHLKAEQVRE ENVATFRGSE YFCYDLSQNP IQSSSDEITL SFKTWQRNGL LLHTGKSADY
VNLALKDGAV SLVINLGSGA FEAIVEPVNG KFNDNSWHDI KVTRNLRQVT ISVDGILTTT
GYTQEDYTML GSDDFFYVGG SPSTADLPGS PVSNNFMGCL REVVYKNNDI RLELSRLARI
VDPKMKLQGD IAFKCENVPT LDPINFETPD SYLALPKWNT KRVGSISFDF RTTEPNGLIL
FTHGKPQYRQ EARGPKNTKV DFFAVELLDG ELYLLLDMGS GTIKVKATQA RVNDGSWHHV
DIQRDGRSGI ISVNSRRTPF TANGENEILD LEGDLYLGGL PDSRGVLVLP TELWTAILNY
GYVGCVRDLF IDGRSKDIRQ IAQSQNMTGI RSSCTKATGK QCDSNPCKNS GACKEGWNRY
VCDCTGSGFW GSTCERESSI LSFDGSMYMK VSMPNIMHSE AEDVSLRFMS QRAFGLLMAA
ASRESADTLR LELDSGRVKL TVNLDCVRIN CNTSKGPEVL YAGQKLNDNN WHSVRVVRRG
KHFKLTVDDD MAEGKMAGDH TRLEFNNVET GILTERRFVS SAPSSFIGHL QGLKFNGMQY
IDMCKNGDID FCELNARFGM RFIIADPITF KTKGSYLGLA TLQAYSTMHL FFQFKTTSPD
GFLIFNSGDG NDFIAVELVK GFIHYVFDLG NGPSLLKGNS DNQLNDNQWH NVVITRDGSN
THTLKVDSKS VTQNVNGAKN LDLKGDLFIG GLGPNMYQNL PKLVVSREGF QGCLASVDLN
GRLPDLINDA LFRSGQIERG CEGPSTTCQE DSCANMGVCI QQWENFTCDC TMTSYSGTHC
NDPGTTYIFG KGGGLITYTW PNNERPSTRT DRLAVGFSTT IKDGILVRID SAPRLGDYIM
LHVEEGKVGV TFNIGTVDIS VKEMTAVNDG KYHLVRFTRN GGNATLQVDN WPINEHFPSG
NSDIERYQMA NKKIPFKYTR PVEDWLQEKG RQLTIFNTQA TISIGGNDRK RPYQGQLSGL
YYNGLKVLNM AAEGNANIKV NGSVRLVGDV PNSRGGARTT TSVPPEMSTT FIETTTTLST
TTTRKQRSPP TIQQTTDDIV SSAECSSDDE DLEECDSGHA GGELVIPVLV EDPIDTPSVS
TRSPFIPLPP TLRPVLTIIE TTKESLAMAT EAGVPCLSDR GSDDCDDGDG GDGDDDDDDG
DGMVISGFGS GEAFDSSLPP TDDEDFYTTF SLVTDKILTT SAYEGGYKAL APKWEAKDLR
PSKASEAGRT STTSPPPDPR GTPPAAVPSD TPPKRPAGKM NNRDVKPLQP DIVLLPLPTP
FDADGTKPRG PFITSPMLRT VPVALPTMPG VVRRVPPGAS EVIRESSSTT GMVVGIVSAA
ALCILILLYA MYKYRNRDEG SYQVDETRNY ISNSAQTNGA VIKDKTPSGS AKGGAGSKRP
KDKDKEYYV
//
