ID A0A3P8WSC7_CYNSE Unreviewed; 1665 AA.
AC A0A3P8WSC7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Neurexin-3b {ECO:0000313|Ensembl:ENSCSEP00000029402.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000029402.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000029402.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000029402.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSCSET00000029803.1; ENSCSEP00000029402.1; ENSCSEG00000018780.1.
DR GeneTree; ENSGT00940000167343; -.
DR Proteomes; UP000265120; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR15036:SF85; SP2353, ISOFORM A; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1665
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017994638"
FT TRANSMEM 1588..1608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..203
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 194..231
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 238..420
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 427..619
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 623..660
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 665..828
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 845..1017
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1020..1057
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1061..1260
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1292..1314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1389..1437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1474..1524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1629..1665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1401..1418
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1492..1507
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1665 AA; 182304 MW; 58DDE346BD9293FF CRC64;
MNSSSLPSPI LLLLSTFLCL SGGLEFTGSE GQWARYLRWD ASTKSDLTFQ FKTSQSKGLL
LYFDDGGFCD FLLLSIAAGK LQLIVSIDCA EMTITSHKLV NDSRWHFAAI NRHYLQTGLA
LDGQTQMEEV RPQRQYMKIV SDLFLGGLPG DIRPSAITLP SVLELPPFKG IITDLSYGSK
LPTLINSQKV RLEMMGLCTE NPCENGGICS LADGETYCDC SKTGYVGRYC TEVREENVAT
FRGSEYFCYD LSQNPIQSSS DEITLSFKTW QRNGLLLHTG KSADYVNLAL KDGAVSLVIN
LGSGAFEAIV EPVNGKFNDN SWHDIKVTRN LRQVTISVDG ILTTTGYTQE DYTMLGSDDF
FYVGGSPSTA DLPGSPVSNN FMGCLREVVY KNNDIRLELS RLARIVDPKM KLQGDIAFKC
ENVPTLDPIN FETPDSYLAL PKWNTKRVGS ISFDFRTTEP NGLILFTHGK PQYRQEARGP
KNTKVDFFAV ELLDGELYLL LDMGSGTIKV KATQARVNDG SWHHVDIQRD GRSGIISVNS
RRTPFTANGE NEILDLEGDL YLGGLPDSRG VLVLPTELWT AILNYGYVGC VRDLFIDGRS
KDIRQIAQSQ NMTGIRSSCT KATGKQCDSN PCKNSGACKE GWNRYVCDCT GSGFWGSTCE
RESSILSFDG SMYMKVSMPN IMHSEAEDVS LRFMSQRAFG LLMAAASRES ADTLRLELDS
GRVKLTVNLG KGPEVLYAGQ KLNDNNWHSV RVVRRGKHFK LTVDDDMAEG KMAGDHTRLE
FNNVETGILT ERRFVSSAPS SFIGHLQGLK FNGMQYIDMC KNGDIDFCEL NARFGMRFII
ADPITFKTKG SYLGLATLQA YSTMHLFFQF KTTSPDGFLI FNSGDGNDFI AVELVKGFIH
YVFDLGNGPS LLKGNSDNQL NDNQWHNVVI TRDGSNTHTL KVDSKSVTQN VNGAKNLDLK
GDLFIGGLGP NMYQNLPKLV VSREGFQGCL ASVDLNGRLP DLINDALFRS GQIERGCEGP
STTCQEDSCA NMGVCIQQWE NFTCDCTMTS YSGTHCNDPG TTYIFGKGGG LITYTWPNNE
RPSTRTDRLA VGFSTTIKDG ILVRIDSAPR LGDYIMLHVE EGKVGVTFNI GTVDISVKEM
TAVNDGKYHL VRFTRNGGNA TLQVDNWPIN EHFPSGNSDI ERYQMANKKI PFKYTRPVED
WLQEKGRQLT IFNTQATISI GGNDRKRPYQ GQLSGLYYNG LKVLNMAAEG NANIKVNGSV
RLVGDVPNSR GGARTTTSVP PEMSTTFIET TTTLSTTTTR KQRSPPTIQQ TTDDIVSSAE
CSSDDEDLEE CDSGHAGGEL VIPVLVEDPI DTPSVSTRSP FIPLPPTLRP VLTIIETTKE
SLAMATEAGV PCLSDRGSDD CDDGDGGDGD DDDDDGDGMV ISGFGSGEAF DSSLPPTDDE
DFYTTFSLVT DKILTTSAYE GGYKALAPKW EAKDLRPSKA SEAGRTSTTS PPPDPRGTPP
AAVPSDTPPK RPAGKMNNRD VKPLQPDIVL LPLPTPFDAD GTKPRGPFIT SPMLRTVPVA
LPTMPGVVRR VPPGASEVIR ESSSTTGMVV GIVSAAALCI LILLYAMYKY RNRDEGSYQV
DETRNYISNS AQTNGAVIKD KTPSGSAKGG AGSKRPKDKD KEYYV
//
