ID A0A3P8WSQ7_CYNSE Unreviewed; 675 AA.
AC A0A3P8WSQ7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Leiomodin 1 {ECO:0000313|Ensembl:ENSCSEP00000029537.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000029537.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000029537.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000029537.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}.
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DR RefSeq; XP_008319318.1; XM_008321096.2.
DR AlphaFoldDB; A0A3P8WSQ7; -.
DR Ensembl; ENSCSET00000029938.1; ENSCSEP00000029537.1; ENSCSEG00000018923.1.
DR GeneID; 103386697; -.
DR KEGG; csem:103386697; -.
DR CTD; 25802; -.
DR GeneTree; ENSGT00940000156567; -.
DR OMA; ELKMDMM; -.
DR OrthoDB; 2883785at2759; -.
DR Proteomes; UP000265120; Chromosome 11.
DR GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005523; F:tropomyosin binding; IEA:InterPro.
DR GO; GO:0051694; P:pointed-end actin filament capping; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR004934; TMOD.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR10901:SF5; LEIOMODIN-1; 1.
DR PANTHER; PTHR10901; TROPOMODULIN; 1.
DR Pfam; PF02205; WH2; 1.
DR SMART; SM00246; WH2; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 649..668
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..637
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 75859 MW; BBC79C32CFC499FA CRC64;
MSRRKVRGLT RTGRQVSEDP DLDTLLSTLS PEEMEELEKD MMKVPDLKPE DGAIIVQGES
QGFQPSTTNN LLDAKCDSRR QSDTKGRLSQ RDQSFEGDPK KESRKQEYLR KMGLSQEGSE
DINDGLQRQA SDSSERDAKV DNRNGKGPER SKEESSQVSG RYRKQPCKGI DAKEKNDEEK
CEDNRLRDRK ETRESSGSKT KDMISRLQEK KEDSREKERR EDGKRRDESK TKDIISKLRE
KSEKEKERKS ESIRTQGLVS KLVEKQSRAK ESPESKSEER PKAKAEEKKA QDKSKSDVRL
ERPLTEEGDT RVKHDKAEQR TDREELVNHT DHVKEKVKKT DEEKKPEGEK EGDESKENVS
KATESVKLGN CVSKNTPNSK TKEEEVDEDA SMFDELMEQV RSNDPSLTEL NVNNSEVIKT
KTLIEFAEAL HNNSHVKTFA LANCRADDHV AYAIAGTIRN NDTITSINID SNHLTGKGIL
SLIQALQHNS TLTELRFQNQ RHICGGKTEM EMVKILKENT TLLKLGYHFE LAGPRMTTTN
ILSRNMDRQR QKRLQEQKQA QANGEKKESL DVPKSGGGGS LRSSPRASPK PSPLPSPMPS
PKLTPKKRAG GPAPPPPPPP PGGGPPPPPP PPMIDGDTPK NSPSRGKNSR DQLLASIRGS
NIMQLKKVPV PKWLQ
//
