ID A0A3P8WUC3_CYNSE Unreviewed; 589 AA.
AC A0A3P8WUC3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Amyloid beta A4 precursor protein-binding family B member 1-interacting protein {ECO:0000256|ARBA:ARBA00040699};
DE AltName: Full=APBB1-interacting protein 1 {ECO:0000256|ARBA:ARBA00042746};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000030112.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000030112.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000030112.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MRL family. {ECO:0000256|ARBA:ARBA00038382}.
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DR STRING; 244447.ENSCSEP00000030112; -.
DR Ensembl; ENSCSET00000030517.1; ENSCSEP00000030112.1; ENSCSEG00000019276.1.
DR GeneTree; ENSGT00940000156105; -.
DR InParanoid; A0A3P8WUC3; -.
DR Proteomes; UP000265120; Chromosome 3.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243:SF14; AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 103..189
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 233..342
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 22..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..532
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 64418 MW; 5F7D857251BEF207 CRC64;
DALMADLVAD LSATEEKLAA EIEGLKVPSP TPLPSGLPAP PPKVLTSSSS DSPASPASSS
FHTPTSSITS PLPPPPPQEE IEAQLKADKI KLALEKLKEA KVKKLVVKVL MNDGSSKTLM
VDERQTVREV LDNLFEKTHC DCSVAWSLFE TNPELQLERS FEDHENLVEP LLAWTRDTEN
QILFKEWKQK YEVFKNPQTF YLWKKDKKTL KDINNKDKEI LVQENFCGSS IIVPDLEGVL
YLKEDGKKHW KQRLFQLRAS GIYYVPKGKT KSSRDLICFL QLDNVNIYYG SDFKSKHKAP
TDFCFVLKHP QIQKDSQYIK YLCCDDITSL NLWVTGIRIA KYGATLYNNF KAAEKKAVVD
AAWTNRCTPS SSEQSTPSPT TQPFLPHLLQ TQPFILHPLP WXXXXXXXXX XXXXXXXXXX
XXXXAMDLPP PPPPPPEEDS IDAPPNFLPP PPPAVGSMLP PPPLSPYSGR SLPPPPPPSC
FKGFNQSLPP PPPDPGFLPP PPPPQPLMTA GGVPPPPPPP PPPPPPAAAS PTAAPRPSLR
PVGSVKKMPP APPKRTTPTL GGGGGGGGGD GGDLMSELML AMQKKRGNN
//
