ID A0A3P8WW81_CYNSE Unreviewed; 403 AA.
AC A0A3P8WW81;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=SHC adaptor protein 3 {ECO:0000313|Ensembl:ENSCSEP00000031044.1};
GN Name=SHC3 {ECO:0000313|Ensembl:ENSCSEP00000031044.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000031044.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000031044.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000031044.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8WW81; -.
DR STRING; 244447.ENSCSEP00000031044; -.
DR Ensembl; ENSCSET00000031451.1; ENSCSEP00000031044.1; ENSCSEG00000019867.1.
DR GeneTree; ENSGT00950000182870; -.
DR InParanoid; A0A3P8WW81; -.
DR OMA; NTQRIPQ; -.
DR Proteomes; UP000265120; Chromosome 14.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01209; PTB_Shc; 1.
DR CDD; cd09925; SH2_SHC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006019; PID_Shc-like.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035676; SHC_SH2.
DR PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1.
DR PANTHER; PTHR10337:SF4; SHC-TRANSFORMING PROTEIN 3; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00629; SHCPIDOMAIN.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 1..90
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 308..399
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 403 AA; 44258 MW; 6107E2BD161BAABE CRC64;
MSINLNISTS SLNLMTPDCK QIIANHHMQS ISFASGGDPE TTDHVAYVAK DPVNRRACHI
LECSEGLAQD VISTIGQAFD LRFQQYLQCP STKSSSTHMD THDRALNMEE LTWTEEEEES
TEHPYYNNIP GKMPPPGGFI DTRLSSQTAA TDGCQTGPGS VDQTYYHGRH CGENWGDERK
SIFIQQASFD IGSLPEIKGQ AAKTAEMPMY VNTQQIDAQV LAALQAEAEN VTKGIAAAAA
AKESPQKDLF DMKPFEDAIQ SQSHLPCQGQ SQTQISGLHK AASVDNSSPL LVRSLAFRAQ
EELEGQTWYH GEMSRRDAEK LLKNDGDFLV RTSTTNPGSY VLTGMHFGLA KHLLLVDPEG
TVRTKDHIFD SISHLIGHHR DNNLPIVSAG SELCLLQPVG KKH
//
