ID A0A3P8WWM1_CYNSE Unreviewed; 567 AA.
AC A0A3P8WWM1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Matrilin 4 {ECO:0000313|Ensembl:ENSCSEP00000031184.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000031184.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000031184.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000031184.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; A0A3P8WWM1; -.
DR STRING; 244447.ENSCSEP00000031184; -.
DR Ensembl; ENSCSET00000031591.1; ENSCSEP00000031184.1; ENSCSEG00000019948.1.
DR GeneTree; ENSGT00940000157086; -.
DR InParanoid; A0A3P8WWM1; -.
DR OMA; DKRSCSM; -.
DR Proteomes; UP000265120; Chromosome 11.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 1.20.5.30; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036337; Matrilin_cc_sf.
DR InterPro; IPR019466; Matrilin_coiled-coil_trimer.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF14; MATRILIN-4; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF10393; Matrilin_ccoil; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM01279; Matrilin_ccoil; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF58002; Chicken cartilage matrix protein; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 31..207
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 339..514
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 567 AA; 63069 MW; D88E9D8B83DA670E CRC64;
MFLRDCLKGD CWCCFPRILS SEQKCKSGPV DLVFLIDSSR SVRPHEFETM RKFMIDILDT
LDIGPNNTRV GVVQYSSQVR SEFSLKTHKN LESMVKNINQ IIPLAQGTMT GLAIKYVMNV
AFTEQEGDRP KVPNVAVIVT DGRPQDRVAE VASEARDKGI EIFAVGVARA DMASLRAMAS
PPFEDHVFLV ESFDLIHQFG LQFQDKLCAI DLCSEGKHDC EQICISSPGV YTCACNQGYT
LNQDKKTCTV IDYCSFGNHS CDQECVSVLN GYHCICNEGH RLLEDGKTCQ DLDLCNTVEH
GCQHRCISTP GSYYCICPEG QLLQEDGRSC GTCKSANIDL VLLIDGSKSV RPQNFELVKK
FVNQVVDSLD VSPHGTRVGL VQYSSRVRTE FPLSMYHSAD EIKAAVMKVE YMEKGTMTGL
ALKHMLENSF SEAEGARPAN RNIPRIGLVF TDGRSQDDIT EFAKMAKEAG ITMYAVGVGK
AVEDELREIA SEPVEKHFYY TTDFSAISTI AENLKLNVCP EESQGEIEVK DPCSCENLVE
FQQVTMNSLE QLTTRNILPQ SVRISLC
//
