ID A0A3P8WXK2_CYNSE Unreviewed; 841 AA.
AC A0A3P8WXK2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Taste receptor type 1 member 2 {ECO:0000256|ARBA:ARBA00040704};
DE AltName: Full=Sweet taste receptor T1R2 {ECO:0000256|ARBA:ARBA00042616};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000030116.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000030116.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000030116.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse
CC natural and synthetic sweeteners. {ECO:0000256|ARBA:ARBA00037659}.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3.
CC {ECO:0000256|ARBA:ARBA00038699}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000256|ARBA:ARBA00038492}.
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DR AlphaFoldDB; A0A3P8WXK2; -.
DR STRING; 244447.ENSCSEP00000030116; -.
DR Ensembl; ENSCSET00000030520.1; ENSCSEP00000030116.1; ENSCSEG00000019292.1.
DR GeneTree; ENSGT00940000166394; -.
DR InParanoid; A0A3P8WXK2; -.
DR OMA; EDWAIST; -.
DR OrthoDB; 4096532at2759; -.
DR Proteomes; UP000265120; Chromosome 10.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF517; TASTE RECEPTOR TYPE 1 MEMBER 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Signal {ECO:0000256|SAM:SignalP}; Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..841
FT /note="Taste receptor type 1 member 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018035494"
FT TRANSMEM 570..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 734..751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 763..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 791..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 568..833
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 841 AA; 93021 MW; 6FDE279642D42EFB CRC64;
MLSKLFLFLG CLSVQKTDAE MYVISQGQGL QLQGNFSIAG LFPLHYADEP SGDTPALGLC
NEGTPNSHGY HLMQAMRFAV EEINNRSGPH HLLPGVKLGY QMYDICSVAA SILASLELLQ
QQTQNSSTPG IEEDSGYSNK AVAVIGPDSS SKTFTPASLL GVYLMPQISY EATNELLSNK
ILYPAFLRTI PSDKNQVHAM IQLLIRYKWT WVALLGSDNA YGLTGMQSLS KQAPEYGICI
AYQGVIPSLK ADTVQTMRNM VENILKTKVN TIVVFSSKSK LSGFFPYVVE RNVTGKVWIG
TEDWSVATLI SGIPGIHTIG TVIGVSIKSV VFSSFEDFSK KVVQASLQHT DTQKTSISDN
DCLQSTDLYS LARNNFSLEQ YDINSSFNVY KAVYAVAHAL HQALRCNSEV CQHRKVHSRE
LLFWLKKVQF SLGESFVDFD ENGDPNSEYN IVTWVWRKAV WTLRVVGSFQ GDSLRLTVDD
TQIEWHNAEE SESVPLSICS PPCPRGHKRL LTGQHNCCFS CQPCPAATFL NMSDPTICQP
CLPEQWSPPI SDHCLNRTVL LLAWDAPLSI ALLFFLATCL LMTLSFAVIL LVNLNTPVAK
SAGGRTCLLM LAALTAATLS SLCHFGPPSS LACILKQPLF IVSFTVCLAC ITVRSLQVVC
IFKFASKLPP AYDKWAKKPG PEITIFLMSV VILLISALRE ALNPPKPSQD LNFYKDSIIL
ECSNTLAPGS MLELAYVFLL SALSFCFSYM GKDLPANYNE AKCVTFSLMV YMISWMSFFT
LYLISRGPFT MAAHVFAILF SVLALLGGYF LPKIYIIVLK PQMNTTAHFQ NCIQMYTMSK
Q
//
