ID A0A3P8WYP9_CYNSE Unreviewed; 1190 AA.
AC A0A3P8WYP9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 4-like {ECO:0000313|Ensembl:ENSCSEP00000030516.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000030516.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000030516.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000030516.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3P8WYP9; -.
DR STRING; 244447.ENSCSEP00000030516; -.
DR Ensembl; ENSCSET00000030921.1; ENSCSEP00000030516.1; ENSCSEG00000019535.1.
DR GeneTree; ENSGT00940000158693; -.
DR InParanoid; A0A3P8WYP9; -.
DR OMA; NSESYWK; -.
DR Proteomes; UP000265120; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF6; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 772..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 851..869
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1002..1027
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..326
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 787..1038
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 1190 AA; 135608 MW; BE751AAD836C6F90 CRC64;
RDEKELRLTG VADTGTQSWI PKIIKKRECT TFVEDTLCGG TLCQCGGSRD SHASVALGDY
FSTAIINHWD SAQHSSEYPT DAFGELQFAG ASKRHSYFLR LSWNTPPSML YTLMTTHWGL
PAPNLVVSVV GGEGSTKMKT WVREVLRQGL VKASQSTGAW ILTAGLREGV GRCVGEAVRD
HATAAASISL SKVVAIGIAP WGLVHNREQL VNPQGSFPAK YYVRNTTQDS CCLDNNYQAF
LLVDDGSVGR TGGEIGFRAK LEDYISHQRT GSGSIDIPVL CMLVSGETSM LERVDLSLKN
SMPWLVLAGS GGTADFISDM LENLSSAPVT QSSSEGDGEA APSVDLKERV AERVKKHFSS
EVEIDKLVEQ ALSIYHNRDL ITIYNGEQEG CVQSAVLYAD FYSDFFFTAS KNRTSVDDSP
YNEELKLAVT WNRVDIAKSE LFNGNIQWRY KDLEESMTDA LINDKPQFVR LFTENGLNIL
DYLTYGRLEC LYRSVPDGTL LYQLLQRHLL ERIGTTAPVS TQSNQQGSPY EMEMLELLMG
DICQAFYYDA LGLNQITSKR RALRMATFFW EMTAESVLSA LSGCKILREL SKLENETETK
VSMKELAQNF ENLAHDLFSS CYRSNESRAF TLLIRKSPVW GGTTCLQMGM SADARLFFSN
DGVQSLLSQI WWGDMKRNTD VWKLLLTFLC PFLCYTNLIT FRNQEDHHQE EEKPNEEGAG
RDSDSLYGHT VFSFSDIKHI CLFTFLYLLY TGIPHIHRPP KRPFIVSRWR QFWFAPVTSF
LGNVLMYFLF LLLFAYVLLV DFKPPPKFGP SITEYVLYFW VFTMVCEEIR EVSTGTGITL
DFQMRVYIQD VWNKCNLAAI ILFVIGLICR MFHWSHGFGR EVLCVDYMVF TLRLIHIFAI
HKQLGPKIII VGKMVKDVFF FLFFLGVWLM AYGVANQALI YSYDPSPDRI FRRVFYRPYL
HIFGQIPVEE MDVGKDWDKP CTDNVTMIED GAEPCRTLYS NWLVVILLVV YLLVTNILLI
NLLIAMFSST FSEVQANSDI YWKFQRYTLI VQYHSRPSLA PPFIILSHLN LFIKRIIRKV
PSVKIYHFVL QLTGKAANRL MTWETIQKED FLTTQNKIQK SSDSERLKRI VDGVLKHMSE
SRDFEHRIRA LENEVEYCSN ALSWIVDTLA QSNMFKPTRP PPTLRGMTRF
//
