ID A0A3P8WZE0_CYNSE Unreviewed; 432 AA.
AC A0A3P8WZE0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=[histone H3]-lysine(4) N-trimethyltransferase {ECO:0000256|ARBA:ARBA00012182};
DE EC=2.1.1.354 {ECO:0000256|ARBA:ARBA00012182};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000032144.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000032144.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000032144.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) +
CC N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60260, Rhea:RHEA-COMP:15537, Rhea:RHEA-
CC COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.354;
CC Evidence={ECO:0000256|ARBA:ARBA00000944};
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DR RefSeq; XP_008311167.1; XM_008312945.1.
DR AlphaFoldDB; A0A3P8WZE0; -.
DR STRING; 244447.ENSCSEP00000032144; -.
DR Ensembl; ENSCSET00000032564.1; ENSCSEP00000032144.1; ENSCSEG00000020640.1.
DR GeneID; 103380835; -.
DR KEGG; csem:103380835; -.
DR CTD; 568616; -.
DR GeneTree; ENSGT00940000166832; -.
DR InParanoid; A0A3P8WZE0; -.
DR OMA; GEMQSHA; -.
DR OrthoDB; 166337at2759; -.
DR Proteomes; UP000265120; Chromosome 7.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.220.160; -; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR12197; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD; 1.
DR PANTHER; PTHR12197:SF290; N-LYSINE METHYLTRANSFERASE SMYD2-B; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 6..240
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 51..89
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
SQ SEQUENCE 432 AA; 49479 MW; 54C0568EB6FF768C CRC64;
MTGSIKGIER FESPGKGRGL RVTKAFKVGE LLFSCPAFSH VLSVKERGYY CEFCFTRKEG
LAKCGKCKKA FYCNVKCQKA DWAMHKLECS AITAFGEKWC PSEMTRLVAR ILAKTKSQKE
RCVSEKILLI GEMQSHVEDV DNENREMNEG NIAELHQFYS KHLDFPDHKD LLTLFSQVAC
NGFTIEDDEL SHLGTAVYPD VALINHSCLP SVIVTYKGTS AEIRAVQNMK PGDEVLISYI
DLLYPTDDRN NRLRESYYFS CDCQECKTKS KDKKKLKLRK RSDPIEPEVV NNMVRYARKS
IREFRACKNI KTPGELLEMC EHSMEEMGSV FDDSNVYMLH MVYQAMGVCL YMEDVEGAIR
YGEKILKPYF QLYPPFSLNV SSIYLKMGRL YMVMDRNSVG VGLLKKALAI MEVTHGKDHL
YLAELRKEIA QK
//
