ID   A0A3P8WZK0_CYNSE        Unreviewed;       688 AA.
AC   A0A3P8WZK0;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Phosphatidylinositol binding clathrin assembly protein {ECO:0000313|Ensembl:ENSCSEP00000030115.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000030115.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000030115.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000030115.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC       {ECO:0000256|ARBA:ARBA00008011}.
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DR   AlphaFoldDB; A0A3P8WZK0; -.
DR   STRING; 244447.ENSCSEP00000030115; -.
DR   Ensembl; ENSCSET00000030519.1; ENSCSEP00000030115.1; ENSCSEG00000019258.1.
DR   GeneTree; ENSGT00950000183068; -.
DR   InParanoid; A0A3P8WZK0; -.
DR   Proteomes; UP000265120; Chromosome 19.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR   GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR   CDD; cd16985; ANTH_N_AP180; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 1.20.58.150; ANTH domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR014712; ANTH_dom_sf.
DR   InterPro; IPR045192; AP180-like.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR   PANTHER; PTHR22951:SF16; PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF89009; GAT-like domain; 1.
DR   PROSITE; PS50942; ENTH; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT   DOMAIN          14..145
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50942"
FT   REGION          570..601
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          643..675
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        581..601
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        656..670
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   688 AA;  75004 MW;  876DF7C1EC1D355E CRC64;
     MSGQSITDRI TAAQHSVTGS AISKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA
     DTLFERTTNT SWVVVFKSLT TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM
     STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GSDGLMRTMN TEKLLKTIPI IQNQMDVLLD
     FNVNANELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKLQC KDGLDIYKKF
     LTRMTRISEF LKVAEQVGID RGDIPDLSQF TVCAPSSLLD ALEQHLASLE GKKVKDSTAA
     SRASTLSNAV SSLANTGISF TKVDEREKQA ALEEEQARLK ALKRLKELQK NPAVATTDSS
     PVSTIGGTIN SAPAIDLFST PSSTNSAPKA ANDLLDLQPA FQQPLSLPTT NSWGDPFTYV
     AEAVEESTPN SNPFITPPVV DAVQPSAVSS DVGRMSCRTP SHEVFDSFCG PSPYSTLFQS
     EPPAVAGLFR GFTASPTQQQ PQNSQGLNVD FDSVFGNNAN ANNMDSTVAS SPNQGMTLNG
     QQPNKLVSND LDSSLANLVG NLGINNGTAK NDLHWSQPGE KKLTGGTNWQ PKTAPSTTWN
     PATMAPSVMA FSATTPTGMM AYAMPPHVGS MMMTQPTMMY TQPVMRPPNP FGPNPGAQSP
     VTSSPSSLSP LRAPGKDPFA HLFLQNFL
//