ID A0A3P8X0K7_CYNSE Unreviewed; 892 AA.
AC A0A3P8X0K7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=NACHT, LRR and PYD domains-containing protein 12-like {ECO:0000313|Ensembl:ENSCSEP00000033188.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000033188.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000033188.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000033188.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR RefSeq; XP_008317637.1; XM_008319415.2.
DR RefSeq; XP_016891659.1; XM_017036170.1.
DR AlphaFoldDB; A0A3P8X0K7; -.
DR Ensembl; ENSCSET00000033615.1; ENSCSEP00000033188.1; ENSCSEG00000021305.1.
DR GeneID; 103385496; -.
DR KEGG; csem:103385496; -.
DR GeneTree; ENSGT01100000263573; -.
DR InParanoid; A0A3P8X0K7; -.
DR OMA; HGMQEMN; -.
DR OrthoDB; 55870at2759; -.
DR Proteomes; UP000265120; Chromosome 10.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR SMART; SM00368; LRR_RI; 9.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 66..200
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 892 AA; 98093 MW; 6F689BCD400B44A6 CRC64;
MDKTMVLSHL LLETRGTPTL LGGEPLARVI KSNKYVVQPS TEAQQADTEV DTLDRALHTA
LCAEVKAVLL TGPEGSGKTT ILEKLMVDWA RGDALQHFSY IFYFGRCELK ALKGLVSLET
LILQHWTNRS APVSVDVLLQ EPEKVLFVFD DLDQCELQLE PSAHSPCSNP ALAMSMSCLV
SSLLHGSVLK GSVSLVSARS AEGLRSESFN RLEVPGFLKA QRQAYVHRFF SDSTAGTTAS
AQMERTLGFH EFCSSPRFCW TVCSLYQTLM DAGVELPETL SQLCVHILVQ LLKEVSTDQT
HNRELVLVLG RLASHCLLHQ HPRYTKEELC SAGFSPFLSQ IHVFMPVDAD LESCDFSFVS
RPMQEFILAL SVFLDKSPPG GVSKMLEEHR GSAGYLDLFL AGLSEPQQYR PLEALLGPLD
PDPIMGFRRW FKSSSEKVLQ GYDKDQQLHC FRLLHQAQSE TLVRETVTAS ARTGIGLGDM
DLHSCVALSY VVSCLGEMKL LKLYRTRDLT EEKARVLAPV MSLSRKILLT YSSLTTGAVR
HLASALTTGV TSELDLSHTG LGDEKFKVLS DGLKNCALLK IRLPSCTLTE VACDHLVTIL
TSGSSQLCEL ELMFNQFGDQ GFVKLCSALH SPHCKLQLLQ LQANNLTAVS MESLSAALRS
GHSRLRSVNL TQNRITDSGV RALCQSLRQR SCQLSSLNLF DNDLTHSCCH DLMEALTSAN
SSLLELDLSL NDLGQEGALL LCQALTHPGC ALKKLVLKRC ELTPVVFEEL GSLLRGGSSR
LCSLDVGINN VGDEAVKHLL AAVADPQCLL EELDLEMTGL TDDCLEHLCT AIQSSRTLKN
LELRNNSLTD SSVPALVQVV EDSTSMMELN LKYNDFSEDV FPCLDSCAKV RY
//
