ID A0A3P8X1G8_CYNSE Unreviewed; 728 AA.
AC A0A3P8X1G8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Spondin-1 {ECO:0000256|ARBA:ARBA00019594};
DE AltName: Full=F-spondin {ECO:0000256|ARBA:ARBA00030964};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000033483.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000033483.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000033483.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR AlphaFoldDB; A0A3P8X1G8; -.
DR STRING; 244447.ENSCSEP00000033483; -.
DR Ensembl; ENSCSET00000033917.1; ENSCSEP00000033483.1; ENSCSEG00000021488.1.
DR GeneTree; ENSGT00940000154910; -.
DR InParanoid; A0A3P8X1G8; -.
DR OMA; MMPPKEG; -.
DR Proteomes; UP000265120; Chromosome 6.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR InterPro; IPR009465; Spondin_N.
DR InterPro; IPR038678; Spondin_N_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR NCBIfam; NF038123; NF038123_dom; 1.
DR PANTHER; PTHR11311; SPONDIN; 1.
DR PANTHER; PTHR11311:SF16; SPONDIN-1; 1.
DR Pfam; PF02014; Reeler; 1.
DR Pfam; PF06468; Spond_N; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 3.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS51019; REELIN; 1.
DR PROSITE; PS51020; SPONDIN; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..728
FT /note="Spondin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017961201"
FT DOMAIN 23..191
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 191..384
FT /note="Spondin"
FT /evidence="ECO:0000259|PROSITE:PS51020"
SQ SEQUENCE 728 AA; 81134 MW; B089907D1E42F938 CRC64;
PAPAPAAVPA PAAVVLLAVV LQLRSPAPSA GGRSDGYCGR ILRAQTQGTR RDGHHEFRLR
VEGDPENYQP GSTYRVVLLA TSPAYFRGFT LIALREGREG TRDEDYAGQF QIIDEDDTQF
MTNCPPAVTE STPRRRTRIQ VFWTAPPAGT GCVILKASIV QKRVIYFQEE GSLTVRLCEK
EPALDGATET PALECCACGT AKYRLTFYGN WSEKVHPKDY PRRANHWSAL IGASHSRSYV
LWEYGGYASE GVRQVAEFGS PIKMEEEIRQ KGDEVLTVIK TKAQWPAWQP LNLRAAPSAE
FSVDRSRHLM SFLTMLGPSP DWNVGLSGED LCTKECGWVQ RLVTDLIPWD AGTDSGVTYE
SPNKPAIPQE KIRPLTSLDH PQSPFYDPEG GAINPVARLV VERIARKGEQ CNVVPDTIDD
IVADIGQEEK DEDDTPETCI YSSWSPWSAC SSATCDKGRR MRQRMLKAQL DLSVPCPHTQ
DFQPCMGPGC SMEAPSSCVV TEWREWDPCS ATCGQGMRRR ERMVKMPPID GSMCKVEVAE
VDKCMMPECH TIRCMFSPWS DWSDCSVTCG RGLRTRQRML KSEPSAECAE ELEQTEKCML
PECPVDCMLS EWSEWSECNK SCGKGHTIRT RMVKLEPQFG GVQCPETIQR KKCKIRKFPG
RHLSVSEDMC EVMEKSSFCG VRSRRALDGA ALAQKHRSSR SQGEEGEVVW GGEGEWAAAQ
ISFHLKDS
//
