ID A0A3P8X2Y6_CYNSE Unreviewed; 1014 AA.
AC A0A3P8X2Y6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Solute carrier family 12 member 7-like {ECO:0000313|Ensembl:ENSCSEP00000033177.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000033177.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000033177.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000033177.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR RefSeq; XP_008333065.1; XM_008334843.1.
DR RefSeq; XP_008333066.1; XM_008334844.1.
DR RefSeq; XP_008333067.1; XM_008334845.1.
DR RefSeq; XP_016897720.1; XM_017042231.1.
DR AlphaFoldDB; A0A3P8X2Y6; -.
DR Ensembl; ENSCSET00000033604.1; ENSCSEP00000033177.1; ENSCSEG00000021296.1.
DR GeneID; 103396662; -.
DR GeneTree; ENSGT00940000157657; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000265120; Chromosome 20.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 54..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..226
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 352..627
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 641..759
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 753..1014
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1014 AA; 112988 MW; 6BEB2E13F121913A CRC64;
MALFEEEMDR SPMVSSLLNK LANYTNLTQG VREHEEEAEN EDGVRRVPVM VPQMGTFIGV
YLPCMQNILG VILFLRLTWI VGTAGILGSF AIVSMCCICT LLTTISMSAI ATNGVVPAGG
SYYMISRSLG PEFGGAVGIC LYLGTTFAGS MYILGTIEIL LTYIVPTAKV FKEGGDTDFL
NNMRVYGTCC LVLMALVVFV GVKYVNKLAL VFLACVILSI MATYAGVVKT LIEPPEFTVC
LLGNRSLRNE KFETCAKTEL VKNETRTTDL WPLFCDNKYL NATCDEYFIV NNLTEIQAVP
GLLSGVIKDN LWGNYDPAGE MLEKKSQPSV PVPEQTEDTK KPYVFNDITT YFTLLVGIYF
PSVTGIMAGS NRSGDLRDAQ RSIPIGTIMA ILTTSFIYIS CVVLFGACIE GVVLRDKFGF
SVKKNPVIGI LAWPSPWVIV IGSFFSCCGA GLQSLTGAPR LLQAIARDGI IPFLQVFGHG
KANNEPTWAL LLTVGICEIG ILIASLDAVA PILSMFFLMC YLFVNLACAV QTLLRTPNWR
PRFKFYHWTL SFLGMSLCLS LMFVSSWYYA LVAIVIAGCI YKYIEYRGAE KEWGDGIRGL
SLNAARYALI RLEEVPLHTK NWRPQLLVLC KLDSNLKVKH PHLLSFTSQL KAGKGLTIVS
SVLEGTYMTR GADAKTGEEN LKAAMAAEKT KGFSHVVVAS NLRDGFSLLI QSAGLGGMKH
NAVLMAWPAG WKLAQDSSAR QNFIETVRET TSAEQALLVA KNIDSFPSNQ ERLTEGTIDV
WWIVHDGGLL MLLPFLLNQH KVWRKCKMRI FTVAQMDDNS IQMKKDLQMF VYHLRLDAVV
EVVEMHGSDI SAFTYEKTLM MEQRSQMLKQ MQLSRTEKER EAQLIHDRNT ATNAKAARQT
TPDHVHMTWT KDKVINERNK HRENMAVKDM FNMKPEWENL SQSNVRRMHT AVKLNEAVVK
KSKNSQLVLL NMPGPPKNKK GDENYMEFLE VLMEGLNRVV LVRGGGREVI TIYS
//
