ID A0A3P8X3L8_CYNSE Unreviewed; 451 AA.
AC A0A3P8X3L8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Glial fibrillary acidic protein {ECO:0000256|ARBA:ARBA00018571};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000033664.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000033664.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000033664.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_016896267.1; XM_017040778.1.
DR AlphaFoldDB; A0A3P8X3L8; -.
DR STRING; 244447.ENSCSEP00000033664; -.
DR Ensembl; ENSCSET00000034098.1; ENSCSEP00000033664.1; ENSCSEG00000021600.1.
DR GeneID; 103392664; -.
DR CTD; 2670; -.
DR GeneTree; ENSGT00940000159539; -.
DR InParanoid; A0A3P8X3L8; -.
DR OMA; IMAHQVH; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000265120; Chromosome 17.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF9; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 89..397
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 107..230
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 295..375
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 451 AA; 51944 MW; 468117501E1623E5 CRC64;
MESQRIQSSY RKRFGPQGSS ASASRIGSLS SSRLSWHGTP RTFTHSSPVS RVSLGSASTL
HLLGSPVDRL DFTAESLMKA QFKETRTNEK MEMMGLNDRF ASYIEKVRLL EQQNKILVAE
LNQLKGKEPS HVGDIYQEEL RELRRQVDSL TAGKSKLEIE RDNLAADLAT LKQRLQDENG
LRQDAENNLN TFRQDVDDAA LTRVQLERKI DALQDEINFL KRIHDEEVRE LQEQIMAQQV
HVEPDVSKPD LTTALREIRV QYETMASSNM QETEEWYRSK FADLSDAANR NAEALRVAKQ
ESNEYRRQIQ VLTCDLEALR GTNESLERQL REMEDRFAIE TAGYQDTVSR LEEEIHALKE
EMARHLQEYQ DLLNVKLALD IEIATYRKLL EGEESRITIP VQSFANMQFR DTNLDTKTSE
AHVKRSILVR TVETRDGEII KDTTTERKDL P
//
