ID A0A3P8X3U5_CYNSE Unreviewed; 1514 AA.
AC A0A3P8X3U5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Unc-13 homolog B {ECO:0000313|Ensembl:ENSCSEP00000031720.1};
GN Name=UNC13B {ECO:0000313|Ensembl:ENSCSEP00000031720.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000031720.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000031720.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000031720.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 244447.ENSCSEP00000031720; -.
DR Ensembl; ENSCSET00000032129.1; ENSCSEP00000031720.1; ENSCSEG00000020312.1.
DR GeneTree; ENSGT00940000154929; -.
DR InParanoid; A0A3P8X3U5; -.
DR OMA; WRIVMTN; -.
DR Proteomes; UP000265120; Chromosome 14.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd20859; C1_Munc13-2-like; 1.
DR CDD; cd08394; C2A_Munc13; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF8; PROTEIN UNC-13 HOMOLOG B; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 2.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 3.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 3.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..93
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 441..491
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 547..671
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 978..1121
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1188..1328
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1342..1469
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 160..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1514 AA; 172515 MW; 56DA7AEDFF99768B CRC64;
QWNCCLRIRR CRLFPFNTYV TLKVQNVKST TITVRGDQPC WEQDFMFEIN RLDLGLIVEV
WNKGLIWDTM VGTSWIPLKS IRQSEEEGSG EWLFLDAEVL MKADEIYGTR TPTPHRVLLD
TRFELPFDIP EDEAQYWTGK LEHINTMRIH DEYSLQDDVQ SRPLPFAPSQ CSLDDQDSAV
DDRDSDYRSE TSNSLPPRYH TTAQPNSSLH QYPMGPRLQQ QQHPDSCTNS IHSFDLDYRD
QRGISPVESS RFGSSGNLSQ TSSQLSETGQ ESTGGSELEE SFHSYHSTGF HPSTNGGQPR
TNGHTNGHPG VNEQEVLRSS PELESSLKNK TPPEKTSTKL LRFRDEGPPL PFSASRVRWL
KAINKVRVHG GSGLYGIDSM PDLRKKKPIP LVSDVSLVQA RKAGIASSMA ARSSIKDEEL
KHHVYKKTLQ ALIYPISCTT PHNFEVWTAT TPTYCYECEG LLWGIARQGM RCSECGVKCH
EKCQELLNAD CLQRAAEKSS KHGAEDKTQN IIMAMKDRMK IRERNKPEIF ELIREVFVIS
KAIHAQQMKT IKQSVLDGTS KWSAKITITV VCAQGLQAKD KTGSSDPYVT VQVGKTKKRT
KTIYGNLNPV WEEKFHFECH NSSDRIKVRV WDEDDDIKSR VKQRLKRESD DFLGQSIIEV
RTLSGEMDVW YNLEKRTDKS AVSGAIRLQI NVEIKGEEKV APYHVQYTCL HENLFHHSND
VLGQGVVKIP DPRGDDAWKV YFDDVAQETV DEFAMRYGIE SIYQAMTHFA CLSSKYMCPG
VPAVMSTLLA NINAFYAHTT ASTNVSASDR FSASNFGKER FVKLLDQLHN SLRIDLSTYR
NHFPASSKDR LQDLKSTVDL LTSITFFRMK VQELQSPPRA SQVVRDCVKA CLNSTFDYIF
NNCHELYNRQ YQPNKEELPL EEQGPSIKNL DFWPKLIMLI VSIIEEDRNS YTPVLNQFPQ
ELSVGKVSAE VMWTLFAQDM KYAMEEHEKH RLCKSTDYMN LHFKVKWLYN EYVKELPNFQ
GVVPDYPSWF LQFVLQWLAE NEDVSVEFMH GALERDKKDG FQQTSEHALF SCSVVDIFTQ
LNQSFEIIKK LECPDPVVMA QYSRRFSKTI AKVLLRYSAI LTKSFPSYID KEKIQCVCPR
VPVSVGVCPQ MDPEASDLLN DLQVKLNNVL DELSSTFGNR YRLKHLNKYT KGPRPKNSFV
LLTLFATVCE KTVLKRVLKE LWRIVMSSLE KSIVLPKGSD TFGAQILSAA KELGQLSKLK
DHMAGEAKSL TPRQCAVMDV ALDTIKQYFH AGGNGLKKAF LEKSPELSSL RHALSLYTQT
TDTLIKTFVT TQHTQGSGLE KQIGEVCVQL EMFTPPGNKE RKVTVKVMGA SDLKWQTSGM
FRPFVEITMI GPQLSDKKRR FQTKSKNNSW SPKFNETFHF VLGNQDGLEC YELQVCVKDY
CFGRADRVVG LAVIQLRDIT EKGNCACWCA LGERIHMDDT GLTAMRILSQ RSNDDVAKEF
VRLKSETRST EEGR
//
