ID A0A3P8X5R1_CYNSE Unreviewed; 1891 AA.
AC A0A3P8X5R1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Myosin heavy chain 7 {ECO:0000313|Ensembl:ENSCSEP00000032800.1};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000032800.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000032800.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000032800.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSCSET00000033224.1; ENSCSEP00000032800.1; ENSCSEG00000020930.1.
DR GeneTree; ENSGT00940000154805; -.
DR Proteomes; UP000265120; Chromosome 20.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF15; SLOW MYOSIN HEAVY CHAIN 1-RELATED; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 32..81
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 85..732
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 609..631
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 796..1851
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1891 AA; 217934 MW; E63C229E6B9C810D CRC64;
MGDSAMREFG LAASYLRKSD KERLEAQTRP FDMKKECFVP DPEVEYIKAT IISRDGDKVT
ANTEFGKTVT VKECDIHPQN PPKFDKIEDM AMFTFLHEPA VLFNLKERYA AWMIYTYSGL
FCVTVNPYKW LPVYNQEVVV AYRGKKRSEA PPHIFSISDN AYQYMLQRKS VYPYHVKSGA
GKTVNTKRVI QYFASIAAVP GGGKKDAASE KKGTLEDQII QANPALEAFG NAKTIRNDNS
SRFGKFIRIH FDNRGKLASA DIETYLLEKS RVTYQLKAER DYHIFYQILS QVKPELLEML
LITNNPYDYA FISQGETTVA SINDSEELMA TDDAFDVLGF TQEEKNSIYK LTGAIMHYGN
MRFKQKQREE QAEADGTEDA DKVAYLMGLN SADLIKCLCH PRVKVGNEWC TRGCSCGCTS
LFNTFEQLCI NFTNEKLQQF FNHHMFVLEQ EEYKKEGIEW TFIDFGMDLQ ACIDLIEKPM
GIMSILEEEC MFPKASDTTF KAKLYDNHLG KSANFQKPRI VKGKPEAHFA LMHYAGTVDY
NINNWLVKNK DPLNETVVGL YQKSTVKLLA TLFANYAGAD SAPEGGKGKG SKKKGSSFQT
VSALHRENLN KLMTNLRSTH PHFVRCIIPN ETKTPGAMEN PLVMHQLRCN GVLEGIRICR
KGFPNRILYG DFKQRYRILN PSAIPEGQFI DNKKASEKLL GSLDIDHTQY KLGHTKVFFK
AGLLGLLEEM RDDRLALIIT RLQARSRGVL ARIEFKKIVE RRDAVLVIQW NIRAFMGVKN
WPWMKMYFKI KPLLKSAESE KEMANMKEEF TKLKEAYAKL EARKKELEEK TVTLLQEKND
LQLQVQTEQD NLCDAEERCE GLIKSKIQLE AKIKELTERL DDEEEMNAEL TAKKRKLEDE
CSELKKDIDD LELTLAKVEK EKHATENKVK NMTEEMAALD EIIAKLTKEK KALQEAHQQT
LDDLQSEEDK VNTLTKAKVK LEQQVDDLEG SLEQEKKIRM DLERAKRKLE GDLKLTQESL
MDLENDKQQL EEHMKKKDFE LSQLNNKIED EQAIAIQLQK KLKELQARIE ELEEELEAER
AARAKVEKQR ADLARELEEI SERLEEAGGA TSAQIEMNKK REAEFQKLRR DLEEATLLHE
STAASLRKKQ ADSVADLGEQ IDNLQRVKQK LEKEKSELRL ELDDVVSSME HIVKTKNNLE
KMCRSLEDQM NEYKTKSEEG QRTINDFTMH KAKLQTENSE LTRQLEEKDS LVSQLTRGKQ
SYTQQIEDLK RQLEEEVKAK NALAHAVQSS RHDCDLLREQ YEEEQEAKGE LQRSMSKANS
EVAQWRTKYE TDAIQRTEEL EEAKKKLAQR LQEAEEAVEA VNAKCSSLEK TKHRLQNEIE
DLMVDVERSN AAAAALDKKQ RNFDKVLAEW KQKYEESQAE LESTQKETRS LSTELFKLKN
SYEESLEHLE TMKRENKNLQ EEIADLTEQI AEGGKSIHEL EKIRKQLEQE KSEIQTALEE
AEASLEHEEG KILRAQLEFN QVKAEIDCLG AECRGRNEAL RIKKKMEGDL NEMEIQLSQA
NRQAAEAQKQ LKSLHAHMKD TQLQLDDSLR ANDDMKENIA IVERRNTLLQ AELEELRAAL
EQTERSRKLA EQELMDVSER VQLLHSQNTG LINQKKKLEA DTSQLQTEVE DAVQECRNAE
EKPKKPITDP AMMAEELKKE QDTSAHLERM KKNMEQTIKD LQHRLDEAEQ IALKGGKKQL
QKLEARVKEL ENEVESEQKK ASDAIKGVRK YERRIKELTY QTEEDRKNLM RLQDLVDKLQ
LKVKSYKKAA EESEEQANNN LAKFRKLQHE LDEAEERADI AESQVNKLRA KSRDVSSKVG
THLFTLFSKM SAYIREAAKN PHLLSIRINH T
//
