ID   A0A3P8X620_CYNSE        Unreviewed;       723 AA.
AC   A0A3P8X620;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=ATG7 autophagy related 7 homolog (S. cerevisiae) {ECO:0000313|Ensembl:ENSCSEP00000033681.1};
GN   Name=ATG7 {ECO:0000313|Ensembl:ENSCSEP00000033681.1};
OS   Cynoglossus semilaevis (Tongue sole).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC   Cynoglossinae; Cynoglossus.
OX   NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000033681.1, ECO:0000313|Proteomes:UP000265120};
RN   [1] {ECO:0000313|Ensembl:ENSCSEP00000033681.1, ECO:0000313|Proteomes:UP000265120}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24487278;
RA   Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA   Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA   Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA   Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA   Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA   Zhao Y., Schartl M., Tang Q., Wang J.;
RT   "Whole-genome sequence of a flatfish provides insights into ZW sex
RT   chromosome evolution and adaptation to a benthic lifestyle.";
RL   Nat. Genet. 46:253-260(2014).
RN   [2] {ECO:0000313|Ensembl:ENSCSEP00000033681.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   STRING; 244447.ENSCSEP00000033681; -.
DR   Ensembl; ENSCSET00000034115.1; ENSCSEP00000033681.1; ENSCSEG00000021612.1.
DR   GeneTree; ENSGT00390000017509; -.
DR   InParanoid; A0A3P8X620; -.
DR   OMA; RQIWDAI; -.
DR   Proteomes; UP000265120; Chromosome 11.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   CDD; cd01486; Apg7; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.40.140.100; Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain; 1.
DR   Gene3D; 3.40.140.70; Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain; 1.
DR   InterPro; IPR032197; Atg7_N.
DR   InterPro; IPR042522; Atg7_N_1.
DR   InterPro; IPR042523; Atg7_N_2.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   PANTHER; PTHR10953:SF3; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7; 1.
DR   Pfam; PF16420; ATG7_N; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT   DOMAIN          17..326
FT                   /note="Ubiquitin-like modifier-activating enzyme Atg7 N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16420"
FT   DOMAIN          343..599
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
FT   REGION          514..541
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        514..539
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   723 AA;  79310 MW;  96EF9D98D067C63D CRC64;
     MASDPSRTAS LSADLKLQFA PFSSALEAGF WHQLTQKKLN DYRLDESPKS IKGYFYNGDP
     VGLPTRLTLE FSAFEVDGPT PAHCCPAVGT LYNTNTLDAF KSTDKKALLE KEANKIWEAI
     KSGAALKDPS ILCTFVLLTF ADLKKYHFYY WFCFPALCFT EGITIVQQPA LLEHVFSATQ
     VLIVSLQEAY DDLQSKRGAI PFFLMKYTES AVQLAPLQDW ETFLQDSKKV TVGFYDPCTL
     AQHPGWPLRN LLITLAYHWR SQLDTVDVLC FRDRTLQGSR SSQHSLMFQV KLPELSANPV
     CPKSVGWEKN PKGAMGPRMV NLSECMDPKR LAESSVDLNL KLMRWRLVPS LDLDKVINTK
     CLLLGAGTLG CNVARTLMGW GVRHLTFVDN AKISYSNPVR QPLYEFEDCL AGGKSKATAA
     VERLTKIFPG VNAKGYNMSI PMPGHPVNFS AATLGQAQKD VEQLEKLISE HDVVXXXXXX
     LVMNAALGFD TFVVMRHGLK KPCVTQTISS QGDSSISCSS DSSSSSTPAG SSPPAPGSSL
     FSNIPGHKLG CYFCNDVVAP GDSTRDRTLD QQCTVSRPGL AMIAGALAVE MMVSILQHSQ
     GGYAVASSSD DRMNEPPTSL GLVPHQIRGF LSRFDNVLPA SLAFDKCTAC SQTVLNHYER
     EGFNFLSKVF NSSHSFLEDL TGLTLLHQET QAAEVKLTCV PTCTLCFVSI NPGHFSDHGV
     TLT
//