ID A0A3P8X8A2_ESOLU Unreviewed; 1572 AA.
AC A0A3P8X8A2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 3 {ECO:0000313|Ensembl:ENSELUP00000000609.2};
GN Name=TRPM3 {ECO:0000313|Ensembl:ENSELUP00000000609.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000000609.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000000609.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000000609.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSELUT00000018766.2; ENSELUP00000000609.2; ENSELUG00000002191.2.
DR GeneTree; ENSGT00940000157366; -.
DR Proteomes; UP000265140; LG13.
DR Bgee; ENSELUG00000002191; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF7; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 715..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 782..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 851..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..269
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 725..963
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1055..1109
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 648..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1490..1572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1433..1462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1490..1507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1553..1572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1572 AA; 176959 MW; 36C7AF637E8C0533 CRC64;
MTKEWQLDLP KLLISVHGGL QNFELQPKLK QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH
VGDALKDHAS KSRGKICTIG IAPWGIVENQ EDLVGKDVVR PYQTMSNPLS KLTVLNSLHS
HFILADNGTT GKYGAEVKLR RQLEKHISLQ KINTRKCDHS SNLFSPVFLS PSLSVGIGQG
VPVVALIVEG GPNVISIVLE YLRDTPPVPV VVCDGSGRAS DILAFGHKYS EEGGIINESL
RDQLLVTIQK TFTYSRTQAQ HLFIILMECM KKKELITVFR MGSEGHQDID LAILTALLKG
ANASAPDQLS LALAWNRVDI ARSQIFIYGQ QWPVGSLEQS MLDALVLDRV DFVKLLIENG
VSMHRFLTLS RLEELYNTRH GPSNTLYHLV RDVKKGNLPP DYRISLIDIG LVIEYLMGGA
YRCNYTRKRF RTLYHNLFGP KRDDMPIRRG RQKTTRKREE EVDIDLDDPE INHFHFPFHE
LMVWAVLMKR QKMALFFWQH GEEAMAKALV ACKLCKAMAH EASENDMVDD ISQELNHNSR
EFGQLAVELL DQSYKQDEQM AMKLLTYELK NWSNATCLQL AVAAKHRDFI AHTCSQMLLT
DMWMGRLRMR KNSGLKVILG LLLPPSILSL EFKNKDEMSY MPQDQDNYLQ EKEEEEPEKP
ANEKEEEDME FTAMLGKVST EASRKKGVGE IQNRHRLIPM GRKIYEFYNA PIVKFWFHTL
AYVAYLMLFN YIVLVKMDLW PSPQEWIVIA YIFTNGIEKM REILMSEPGK LLQKVKVWLQ
EYWNITDLMA ILIFSVGMVL RLQEPPLMSY GRVIYCVNII YWYIRLLDIF GVNKYLGPYV
MMIGKMMIDM MYFVIIMLVV LMSFGVARQA ILNPNEDPSW MLARNIFFMP YWMIYGEVFA
DQIDPPCGQN ITTEDGHVVA LPPCKTGAWI VPAIMACYLL VANILLVNLL IAVFNNTFFE
VKSISNQVWK FQRYQLIMTF YERPILPPPL IIFSHITMVL KHLCCRWRKH DDDERDYGLK
LFITEDELKK VHDFEEQCIE EYFREKDDRF NSSNDERIRV TSERVENMAM RLEEVNEREH
FMKASLQTVD IRLAQMEELI GRIAVALERV TGVERGEVNK ARSRTSSDCT DSAYVLRQGD
SFNSQEGNAY RLPEALEVGA EGSMSPPSPT GLATRTRSHS FFVGGVRERA GADRADRFAK
ERSFSLHRAN SSQSVTSSTA PKESKPLPLA MLSVSQQHRP SSCIDIFVSA SEEAGPAEVF
LDPLRMAPPF QRDSSLHSEI MEAVLSSGRD YSGGSGPGDK PPTEGVFEDS AAADLSLCSA
NLLPDNAMPP WELEPSPPPS AGLLERSKSS RYLSAGGGGY LEEPQLVKSH SLVFTPRVCY
GGLGAGVQVK AAEYTSITDC IDTRCVSAPY PPAERSHSPG GSTSFPFDKA PDMGSSHPER
EAELSHTESD SEDPDDLAPA PEPHRVRGGL GGASGTPFCA TFSRLERANS CSSDESSHPS
LALPSHRKSL SVSERMERGS DRGGRGGLGG PRNPFLRSKS GARPDAKADS LSMRKLTTPS
AFRSFESRHN YT
//
