ID A0A3P8X8U6_ESOLU Unreviewed; 533 AA.
AC A0A3P8X8U6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Polypyrimidine tract binding protein 2 {ECO:0000313|Ensembl:ENSELUP00000000960.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000000960.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000000960.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000000960.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8X8U6; -.
DR Ensembl; ENSELUT00000018206.2; ENSELUP00000000960.2; ENSELUG00000002502.2.
DR GeneTree; ENSGT01050000244924; -.
DR InParanoid; A0A3P8X8U6; -.
DR OMA; XRAQAVL; -.
DR Proteomes; UP000265140; LG21.
DR Bgee; ENSELUG00000002502; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR006536; HnRNP-L/PTB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF16; POLYPYRIMIDINE TRACT-BINDING PROTEIN 2; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF13893; RRM_5; 1.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 4.
DR PROSITE; PS50102; RRM; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..533
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5028234264"
FT DOMAIN 51..135
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 171..247
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 340..414
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 457..531
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 259..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 57684 MW; 0572DC49C4C4FD05 CRC64;
AFIYLFLVFS FLQRGSDELL SSSLYNSNGT SNGSDSKKLR VEDRMEAAPS RVLHIRKLPN
ETTETEVIAL GLPFGKVTNI LTLKGKNQAF LELGTEEAAI TMVNYYSTVT PHVRNVPVFI
QYSNHKELKT DAGNQRAQAV LQAVSAVQGG GTPTSGSTVD LALTAASSPV LRIIIDNMFY
PVTLDVLQQI FSKFGTVMKI ITFTKNNQFQ ALLQFNDPST AQQAKIALDG QNIYNSCCTL
RIDYSKLVNL NVKYNNDKSR DYTRPELPAG DGQPAVDPNM AAAFQGKDSS SLGPGGVGAP
SSLTGLTPLS PGALSPLNAA AAAAAAAGRV ALSGHSGSSG VLLASNLNEE MVTPQSLFTL
FGVYGDCQRV KILYNKKDSA LIQMADANQA QLAMSHLNGQ KMYGKVIRVT LSKHTSVQLP
RDGLDDQGLT KDFTNSPLHR FKKPGSKNFQ NIFPPSTTLH LSNIPADVTE EDLRLLFSNA
GGTVNAFKFF QDHKMALLQM STVEEAIQGL IDLHNYNMGD NHHLRVSFSK STI
//
