ID A0A3P8X9B0_ESOLU Unreviewed; 1238 AA.
AC A0A3P8X9B0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=TBC1 domain family member 4 {ECO:0000313|Ensembl:ENSELUP00000000068.2};
GN Name=TBC1D4 {ECO:0000313|Ensembl:ENSELUP00000000068.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000000068.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000000068.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000000068.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8X9B0; -.
DR Ensembl; ENSELUT00000019709.2; ENSELUP00000000068.2; ENSELUG00000001692.2.
DR GeneTree; ENSGT00940000158486; -.
DR Proteomes; UP000265140; LG16.
DR Bgee; ENSELUG00000001692; Expressed in stomach and 14 other cell types or tissues.
DR CDD; cd00934; PTB; 1.
DR CDD; cd01269; PTB_TBC1D1_like; 1.
DR Gene3D; 1.10.10.2750; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR021785; DUF3350.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR47219:SF13; TBC1 DOMAIN FAMILY MEMBER 4 ISOFORM X1; 1.
DR Pfam; PF11830; DUF3350; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00462; PTB; 2.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 339..411
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 856..1050
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 298..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1238 AA; 140540 MW; B1F3132230D883AE CRC64;
MFTLLQAQMV TGQKKFALWY IGWSSLDRRT TLPMLPWLVA EIRRKSEKNE SGRETGPIQA
REVQIVLTPP FIRCVPSNNT ANSSVFIFEH KAQFISRFIH NSNDLTYFAY LIRSQPDNPE
SEMACHVFRA NDPNQVPEVI SSIRAVSKSA LKENSKPKQD TDEAFYNSQK FEVLYCGKVT
VANKKASSTI IDDCIDKFHQ HELERKRLHI LNDQGSTGNV PMEFIMGDDV DPLSTKVFDQ
GAMEKLDKLK LMVVSNSPSL SSLRAAFPEC ILEDSGFEEQ QEFRARCSSL AGSLQRKSRE
GALKAAPPRR RHASAPNHVQ PSDADKNRTM LFQVGRFEVN LISPDSKTVV LEKKFKDISS
CSQGINKTDH FGFVCRDSGG SGPGQYVCYV FQCACESLVD EVMLTLKQAF STAAALQSAK
TQVKLCEACP MHDLHKLCER IEGLYPPRAK LAIQKFLSQL TDKEQVDIFE RVQRMKPASD
QEENELVILQ LRQLCGTKQK SHLHIGEAPQ VISFHLYKCI SATGGRFKLD ILKNKAKTSL
TSSLENIFSR GANRMRGRLG SMGSFERADD SPGDSPPGTP PGFPEDDTDA PQFRRRAHTF
SHPPVKKRIS FTDTSTQGGQ QGGTQSKVPL RRQQSVNPEL LQSSVSESES TFSLPSSTPT
FLKSFYQGSL GSLGSSYFNP TWFFSNGDGR KRTLSGCSSD SVSAPLTRRE VSWRQKIFLR
VATPINKATS MQHQDHCDMR ELLPLSPRSF DPSVDPLASL LPVTGERPKR TRAQYRALWK
TAIHQQILLL RMEKENKRLE ASRDELHIRK MKLDYQEVGA CTQEVQAYWD RKLSVLGRAK
LLLDKEESMT SSLSPGVPKG RRGEVWLLFS QQHRLRHRLP PGRQAPDTPY QDLLKQLTAQ
QHSILVDLGR TFPTHQYFSA QLGAGQLSLY NLLKAYSLLD TEVGYCQGIS FVAGILLLHM
SEDQAFDMLK FLMYDLGFRR QYRPDMTSLQ IQMYQLSRLL HDYHRELYNH LEEHEICPSL
YAAPWFLTLF ASQFPLGYVA RIFDILFVQG NEVIFKVALC LLSSHEGEIV ECDSFEAIVD
YLKTTIPNLT PTQMEETISK VLEMDISKQL HTYEVEYHVL QDEMVEPIPQ SDESDCLDKL
EKTNNQLKKQ NMDLLEKLQV RNLKIQSLEA TVENFLSRES KMKHTIRSLE QERQFYQKTI
ERMRSYLPLD TLADMEMTHM VKPAQGPNGK AKPAANKP
//
