ID A0A3P8XAK3_ESOLU Unreviewed; 793 AA.
AC A0A3P8XAK3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000001666.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000001666.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000001666.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR RefSeq; XP_010871628.1; XM_010873326.2.
DR AlphaFoldDB; A0A3P8XAK3; -.
DR STRING; 8010.ENSELUP00000001666; -.
DR Ensembl; ENSELUT00000017008.2; ENSELUP00000001666.1; ENSELUG00000003113.2.
DR GeneID; 105012465; -.
DR KEGG; els:105012465; -.
DR GeneTree; ENSGT01090000259987; -.
DR InParanoid; A0A3P8XAK3; -.
DR OMA; SKIDNPC; -.
DR OrthoDB; 5475862at2759; -.
DR Proteomes; UP000265140; LG10.
DR Bgee; ENSELUG00000003113; Expressed in camera-type eye and 8 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF9; INTEGRIN BETA-8; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..793
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017948703"
FT TRANSMEM 705..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..461
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 625..701
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DISULFID 38..461
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 46..56
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 49..84
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 59..73
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 200..207
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 255..296
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 396..408
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 428..673
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 459..463
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 518..523
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 520..553
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 525..538
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 559..564
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 566..575
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 577..584
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 598..603
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 600..648
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 605..615
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 618..621
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 625..634
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 631..699
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 652..680
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 793 AA; 87658 MW; 17AB2C2C9EB6B23A CRC64;
MTSWIRKYCN SILHRVLFCV ILAANITSGR SNSGVSVCSS PPVLSCSECL QRGPLCSWCF
QEGFLDGAVG VRCGLAGTLA MRGCGPEFIE HPEVTVEVNA ATGRTQVSPA EVTVTVRPGS
EARVTVAVRQ LERYPVDLYY LVDVSASMQE NLDQLKTVGV ALSHRMGEYS SDLRLGFGSF
VDKPVSPYIN VHPSKINNPC SDYEVKCRPA HGFHHVLSMT ANMSEFTRVI KRQRISGNMD
TPEGGLDAML QATVCQDVVG WRREAKRLLL LMTDQPSHLA LDGRLAGIVR PHDGLCHMEN
NVYTESTSMD HPSLGQLAEK LLENHIYSLF AVEQQQYQWY EELIRLIPGS NLLFQTPNLI
DLVVDAYTRL LSVVQVSVSV EDRAFRHFLV RVSPLCPVGS VSHDNHSCSN VQPNQTVYFN
VAIGLRSCPD DGDEDDAVLV FVRPVGYNES TVVKVRSRCR CHCGPDRSCH DDITEQQSKC
QADAADRNHS HKDTLPSEGQ LHCRPDGSGV DCSGRGECVC GRCVCERHSL GTTYGRYCEM
DDYSCPYHQG KLCGGRGVCV HSECVCEDGW TGESCGCPVS TATCSLDNGL LCSGRGRCVC
GKCECDDYRH SGTFCELCPT CLSSCQSHWM CIDCHLSHGL SQNAAWQCNH TCTPLVGYVS
DVAVTIDGVW RQCVYMKDNC HYRFHTANTQ LHINTQPECV SSGRYMGTFL SVCVLTFLPG
LVILVVLVLV LQRRALPHSG ATNRQFNSAG KDIYIPTTNE KTVSYRRDHP LGPDRPMEMH
ITIPKMPLGE PWQ
//
