ID A0A3P8XBB4_ESOLU Unreviewed; 564 AA.
AC A0A3P8XBB4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Apoptosis inducing factor mitochondria associated 3 {ECO:0000313|Ensembl:ENSELUP00000001921.2};
GN Name=AIFM3 {ECO:0000313|Ensembl:ENSELUP00000001921.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000001921.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000001921.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000001921.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00006442}.
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DR AlphaFoldDB; A0A3P8XBB4; -.
DR Ensembl; ENSELUT00000016590.2; ENSELUP00000001921.2; ENSELUG00000003338.2.
DR GeneTree; ENSGT00940000160448; -.
DR Proteomes; UP000265140; LG13.
DR Bgee; ENSELUG00000003338; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd03478; Rieske_AIFL_N; 1.
DR Gene3D; 3.30.390.30; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR InterPro; IPR017941; Rieske_2Fe-2S.
DR InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR PANTHER; PTHR43557; APOPTOSIS-INDUCING FACTOR 1; 1.
DR PANTHER; PTHR43557:SF8; APOPTOSIS-INDUCING FACTOR 3; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF00355; Rieske; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00469; PNDRDTASEII.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
DR SUPFAM; SSF50022; ISP domain; 1.
DR PROSITE; PS51296; RIESKE; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 64..154
FT /note="Rieske"
FT /evidence="ECO:0000259|PROSITE:PS51296"
SQ SEQUENCE 564 AA; 61377 MW; 71D8871711A2B16A CRC64;
FNGSSIEVKV ELTLLDKEKD TDVMSPNGKA SPFSDCRPNG ALGHCSDEDS APPRLYQPRD
YVEASVCHVK DLENGQMREV DLGSGRALLI KEHGEFSAIA HKCPHYGAPL VKGVLSKGHV
RCPWHGACFN IATGDIEDFP GLDSLPTFQV TFVDLQSQKR SKAMARCSAV INSSTGFSHI
LIVGSGPAGL VCAETLRQEG FTDRIVMCTM DKHPPYDRPK LSKSLESTAE QLRLRSIDFL
QDHDIELLTE KEAVAVDVKT RAVTFQDGSR MEYRKLFIAT GSKPKPMNYK GQDVKNVFHL
RTPEDANCVA RLANNRNAVI VGTSFVGMEV AAALTDKAHS VSIIGIEAIP FQKALGEKVG
RAIMKSGDVC CLTTVNVIFM FQLKEVLLKS GKVLRADVCV IGTGSRPATG FLKGSGVHMD
SKGFVPVNKT MQTNVEGVFA GGDIVTFPFL GRSNKKVNIP HWQMAHVHGR VAALGMMGRP
TEIKTVPYFW SAMFGKSIRY AGYGEGFDDV VIQGDLDELK FVAFYTRYVL VSQSWSSGPK
GLQVIVFALA ITCVTGGPTF ESGV
//
