ID A0A3P8XBM8_ESOLU Unreviewed; 370 AA.
AC A0A3P8XBM8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011989};
DE EC=4.2.1.47 {ECO:0000256|ARBA:ARBA00011989};
DE AltName: Full=GDP-D-mannose dehydratase {ECO:0000256|ARBA:ARBA00031085};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000000437.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000000437.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000000437.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via
CC de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004912}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. GDP-mannose 4,6-dehydratase subfamily.
CC {ECO:0000256|ARBA:ARBA00009263}.
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DR RefSeq; XP_010896118.1; XM_010897816.1.
DR AlphaFoldDB; A0A3P8XBM8; -.
DR Ensembl; ENSELUT00000019066.2; ENSELUP00000000437.1; ENSELUG00000002034.2.
DR GeneID; 105026389; -.
DR GeneTree; ENSGT00440000033640; -.
DR OrthoDB; 5484740at2759; -.
DR UniPathway; UPA00128; UER00190.
DR Proteomes; UP000265140; LG08.
DR Bgee; ENSELUG00000002034; Expressed in pharyngeal gill and 15 other cell types or tissues.
DR GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR CDD; cd05260; GDP_MD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR HAMAP; MF_00955; GDP_Man_dehydratase; 1.
DR InterPro; IPR006368; GDP_Man_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR01472; gmd; 1.
DR PANTHER; PTHR43715:SF1; GDP-MANNOSE 4,6 DEHYDRATASE; 1.
DR PANTHER; PTHR43715; GDP-MANNOSE 4,6-DEHYDRATASE; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 26..356
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 370 AA; 41738 MW; CFCFB5F494EAA017 CRC64;
MSECTEPSTS TGANGDVRKQ RKVAVITGIT GQDGSYLAEF LLEKGYEVHG ILRRSSSFNT
GRIEHLYQNP QTHTEGNMKL HYGDLTDSTC LVKIINQVKP TEIYNLGAQS HVKISFELAE
YTANVDGVGT LRLLDAIKTC GLTDSVKFYQ ASTSELYGKV QEIPQKETTP FYPRSPYGAA
KLYAYWIVVN FREAYNLFAV NGILFNHESP RRGANFVTRK ISRSVAKIHL GQLESFSLGN
LDSKRDWGHA KDYVEAMWMM LQCEKPEDFV IATGEVHSVR EFVEKSFSHV GKTIVWEGKD
EKEVGRCKET GVVHVKVDPK YYRPTEVEYL QGDSTKALTH LGWKAKITFE ELVKEMVDAD
IQLMKNNPNA
//
