ID A0A3P8XBN3_ESOLU Unreviewed; 463 AA.
AC A0A3P8XBN3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Thymine DNA glycosylase {ECO:0000313|Ensembl:ENSELUP00000002045.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000002045.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000002045.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000002045.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8XBN3; -.
DR Ensembl; ENSELUT00000016386.2; ENSELUP00000002045.1; ENSELUG00000003423.2.
DR GeneTree; ENSGT00390000000987; -.
DR InParanoid; A0A3P8XBN3; -.
DR OMA; ANMVNPE; -.
DR Proteomes; UP000265140; LG19.
DR Bgee; ENSELUG00000003423; Expressed in embryo and 15 other cell types or tissues.
DR GO; GO:0000700; F:mismatch base pair DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0006285; P:base-excision repair, AP site formation; IEA:InterPro.
DR CDD; cd10028; UDG-F2_TDG_MUG; 1.
DR Gene3D; 3.40.470.10; Uracil-DNA glycosylase-like domain; 1.
DR InterPro; IPR015637; MUG/TDG.
DR InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR PANTHER; PTHR12159; G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE; 1.
DR PANTHER; PTHR12159:SF9; G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE; 1.
DR Pfam; PF03167; UDG; 1.
DR SUPFAM; SSF52141; Uracil-DNA glycosylase-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 163..280
FT /note="Uracil-DNA glycosylase-like"
FT /evidence="ECO:0000259|Pfam:PF03167"
FT REGION 46..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 51667 MW; 2A0EC7DF0387A2B9 CRC64;
MYRIQSTQQL QALQGQYPGI NHQYSPHPHY VEAPREERVM AHAQMAVNPE SLAQEEPTNL
AKAPAKKRGR PAQPKEPKPP KMPKPPKEPK PPKPPKEPKP PKEPKAPKAK PGPKPKKGKE
GQEADSTQEK IDETFKKVKK KRDRFKGMTE DEVMNRTLTD ILDYNLDYVI IGINPGLVAA
YVGRWFPGPG NHFWKCLFLS GFTDEQLNHL SDTSLPAKYK IGFTNMVART TPGSKDLSTK
ELREGALILV EKLKKYKPLI AVFNGKCIFE MFCRELFGKK PKKLDFGLQP HKIPDCDVAL
YLMPSSSARC AQFPRAQDKV HFYIKLRELR DQLRGVARSD EIQELEYTFD LGLAKEDAKR
MAIKEEAYDP GYEAAFGGAY VEEGPGPEEG QSNGHCNFSS TDNTSQPNET PDAAEKVNAS
QPTAVATAAE GKLPDGQWMV QSFADQIPDI GGSKEPQAWA GDV
//
