ID A0A3P8XDR9_ESOLU Unreviewed; 945 AA.
AC A0A3P8XDR9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040395};
DE AltName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042170};
GN Name=FARP1 {ECO:0000313|Ensembl:ENSELUP00000001743.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000001743.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000001743.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000001743.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P8XDR9; -.
DR Ensembl; ENSELUT00000016885.2; ENSELUP00000001743.1; ENSELUG00000003196.2.
DR GeneTree; ENSGT00940000155318; -.
DR OMA; NGHEDRK; -.
DR Proteomes; UP000265140; LG16.
DR Bgee; ENSELUG00000003196; Expressed in liver and 14 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Synapse {ECO:0000256|ARBA:ARBA00022599};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT DOMAIN 1..231
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 441..632
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 661..758
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 834..931
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 279..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 107594 MW; D704E612068215B7 CRC64;
MTVWLDLLKP IVKQLRRPKH TVLRFVVKFF PPDHAQLLEE LTRYLFALQI KHDLACGRLT
CNDSSAALLV SHVIQSEIGD FEESQSRQHL LNNSYIPEQM ALMDKIMEFH SKNVGQTPAE
SDYQLLEVAR RLEMYGVRLH PAKDREGSKL SLSVSHTGVL VFQGHTKINA FNWSKVRKLS
FKRKRFLIKL RPDLNQSSYQ DTLEFLMGSR DCCKVFWKIC VEYHAFFRLF EEPKPKPKPV
LFTRGSSFRF SGRTQKQVID YVKDSEFKKI AFDRKHSRVQ YSSSRLSPLP SPHRPQVPKE
NASGAPGDGL GLDSPPRRHW KESVLVSAED PSALRSRGSP SSQRNGARGE DRPGPGGEPG
PARQPQPDHL NTGLASDSPH LSASSGNSQG MVNGQKPVQL FGHSPDGRQP SPLTSPLLND
AGSVRTDDED EVRRKRFPTD RAYFIAKELL TTERTYLKDL EVVTVSFQDA VGKDEATPEP
LKSTIFSHFD PLYKFHSGFL REVEQRLALW EGRSNAHIKG DYQRIGDVML KNLQGLKPLM
AHLQKHSEAL VELEKACRAS RRLEVLVRDF ELQKVCYIPL NVFILRPLHR LTHYKQILER
LCKHYPATHV DFRDSRAALA DVSEVVAQLQ AGMIKMENVQ KLLELKKDLI GVDNLVTPGR
EFIRLGCLSK LSGKGLQQRM FFLFNDVLLY TSRGMTATNQ FKVHGQLPLH GMTIRESEDE
WGVPHAFTLV GQHQSVVVAA SSLSEMEKWM EDIKMAIDLA GSSNGPTSDL LASSLTDNKS
PTEDSCQEAE SEDDLAASRT SLERQAPHRG NTTVHVCWHR NTTVSMVDFS VAVENQLSGN
LLRKFKNSNG WQKLWVVFTN FSLFFYKTHQ DDYPLASLPL LGYSVTIPTE SENIHKDYVF
KLHFKSHVYY FRSESEYTFE RWMEVIRSAT VSASHRRSRK ESHLY
//
