ID A0A3P8XED7_ESOLU Unreviewed; 653 AA.
AC A0A3P8XED7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000002967.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000002967.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000002967.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; A0A3P8XED7; -.
DR Ensembl; ENSELUT00000014809.2; ENSELUP00000002967.2; ENSELUG00000004281.2.
DR GeneTree; ENSGT00940000157537; -.
DR OrthoDB; 534027at2759; -.
DR Proteomes; UP000265140; LG20.
DR Bgee; ENSELUG00000004281; Expressed in muscle tissue and 15 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF40; ANOCTAMIN-10; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 208..231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 243..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 314..337
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 357..379
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 400..421
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 433..455
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 501..524
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 591..613
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 200..626
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 653 AA; 75590 MW; FA60B7B536A16378 CRC64;
MQKGLSVSDS DGSTFAPLVV LELAPNTKEE AVEWLLKRIR DKQQDGGAEL LVEKLSPEDQ
STEKDNPNVY MVGASMRRLL FGAEDVGLFK EFNDGTMRSF TCANRHNFKE FQGDGDSFLS
MAECQYIIKH ELDTLRAKGE AHVPGYPKMK LYPGKSVIRR IQSKGILVQI FPLHENEELK
RLSFSWYKQF KLSFQPLDDI RHYFGEGLAL YFAFLEYFTF ALIPMAIIGI PYYLFDWEDY
DKYTVFAGFN LVWCTVILEL WKRLSASLAY RWGTLSRKKA FEEPRPGFHG ILGFNPVTGR
EEPLYPNFKR QLRIYLVSVP FVLLCLYLSL YVMMIYFEME GWVLMIHDEE PTFWTGVLLF
IPSVIYAVVI EIMNLIYRYA AEYLTNWENH RLESTFQNHL VLKVLVFNFF NCFASLFYIA
FVMQDMGLLR QSLATLLITS QILNQIMEAF LPYWLQRRRN KKAHRRVIKT LADKELPLSD
QVKLEADMST YLGTFDDYLE LFLLFGYVSL FSCVYPLAAV LVVLNNVTEM YSDALKMCKV
FKRPFSEPAA DVGVWQLAFE AMSVIAVVTN CALIGMSPQV KSYFPESDTQ LIMWVVAGEH
LLLAVKFILT FVIPDIPKNI QIKLSRLEFE SLEALKKRIL EKIMGKIIDN PCM
//
