ID A0A3P8XEF0_ESOLU Unreviewed; 2687 AA.
AC A0A3P8XEF0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=von Willebrand factor {ECO:0000313|Ensembl:ENSELUP00000002996.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000002996.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000002996.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000002996.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 8010.ENSELUP00000002996; -.
DR Ensembl; ENSELUT00000014768.2; ENSELUP00000002996.2; ENSELUG00000004316.2.
DR GeneTree; ENSGT00940000155810; -.
DR Proteomes; UP000265140; LG19.
DR Bgee; ENSELUG00000004316; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 5.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF398; MUCIN-2-LIKE-RELATED; 1.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF01826; TIL; 4.
DR Pfam; PF00092; VWA; 2.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00832; C8; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00327; VWA; 2.
DR SMART; SM00214; VWC; 3.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF57603; FnI-like domain; 2.
DR SUPFAM; SSF57567; Serine protease inhibitors; 5.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS50234; VWFA; 2.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 3.
DR PROSITE; PS51233; VWFD; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00039}; Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..2687
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027655758"
FT DOMAIN 25..193
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 370..544
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 849..1008
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1248..1418
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1454..1622
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1805..1989
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2123..2195
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2296..2362
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2451..2516
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2599..2687
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 1425..1447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2599..2649
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 2614..2663
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 2625..2679
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 2629..2681
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 2687 AA; 294933 MW; 4D820887F5C67B1C CRC64;
PMITVTDFYM LCVCVRVLFA VGLSDRCSLF GRHHVHTFDG ILYQFPGDCS YLLAGDCDQR
AFTLLGDFVR GQRSGVTLFL GEVFELHLSV NGHLSQGQKR LSLPYAFQGV FVGSELGFYK
MWSEEFGFSV TIDNQANVAL TMAKHHSNHT CGLCGNFNGE PDDDYTAQEG FLTEDSYDFA
NSWALKGAGE PCRRVSPPSQ SCNTTADTSG LWCSVLQNSP VFLRCANVVS PETFLSICEE
EACHCGQGEG LGAGPDCHCN VLLEFARTCL AHGQLLNGWL EDTPRCPVGM QYKECARSCS
TTCQSLNIQE VCNEECVDGC TCPVGKVIDG DRCVEVSQCS CVHMGRHFPP GSSISQDCNT
CSLLWCRYSG ECMVTGQSHF KTFDNKFFTF SGHCQYLLAK DCTDNAFSVI IETVQCADET
DAVCTRSVTL SLKSLEAMTV KLKHGGVVSV NDLDIRTPMN HGRLRIQRMV QSGVRVLYGN
DLHLEWDGRG HVLLKLWPVW AGNTCGLCGN YNGNQGDDFL SAAGLVEAGP QAFGQSWRIN
GDCNSAPRPD TDPCSLNPKR VRFAEEACGM MMSEVFRPCH FLVNPLPFLR FCRYDVCVCS
NGEECLCSAL ASYAAACSAR GVLLTWRTPE HCAMKCPVGQ VYETCGSVCQ RSCRTLSGKE
PGCTEQTGCE EGCFCPPGQY LSDTGECVSP ELCPCLHDGQ LYQPNDVYAD HNSICYCENG
SMKCSSNEMS ETMLSDMFYE DEQPFSRERR SAPCAPPLRH VGCEGGGQGL ECSRTCQNLD
LPCLSLACRP GCLCPNGTVR HRRECIVPEQ CPCYHNNRAY APGQRITVDC NTCVCENRHW
HCTKQVCDGV CRTVGEGHYI TFDGLQYSFP GLCQYVLVQD QCGGEEGSFR VLVENEACGV
VGHRCAKAVT VFYKGGIITM EHGQVRMRKP VMKGSEVEIV RSGQFFILLL GKHISISWDL
GTRLLERVCG LCGNYDGNLN NDLLSSNNQL EVDSAHFGNS WKVKPSCADA TQPSPPCSNN
IVKLVMVEQS CRVLSGTLFR DCNSLVDPEP YVEMCVEAAC SCPTVGDCVC FCDVIAAYAQ
ACSERGMAVS WRTNDLCPLS CEDLNIAAEV LGGEPCQWRY NTCSSACPIT CQHPEPLPCP
FTCLEGCHAT CPPGQLLDEV SMRCVEPTQC HVCYHDGERI SHGNKVILNH DDPKHCQICH
CENNTLSCKV CPVLEITVST TLPADLTTPT ALPFSTLMPE HSCDRAMDLA FLLDGSAALS
EEDFLSVKEF ILSVVDRFRM GSAHTRATVL LYHSGVKTYD LQWLFKKTVR ELHYSGGDVA
FLDEAVKYLA IHIYDKNKRE HAGRVAIILT ANINPRPLRR TVKLLRTKDI TTLTLALGPE
ASWSQVNEIT KARPDNRAYQ LNSVAELPIN FLEVTDYLCT LGLEPETPKP HPTKPSSPAN
LALTTTTSPA PSKEITFILE GSDSVGEVGF NKSLHFLEEV ISQLAEEDEQ SVRVTVIQYS
VTITVEITRW EIQWHRTQLL QRLREIRWRG GAKTNTGAAI SQTFQEIITD RTSSTTPPLV
FLVTENPPTD VITRPLSHTH SNVFPIGVGR KVTEVDLLPL SSPQRPLMVE DYDSLTSLVH
RVVNITRTTL YPRSPTLPPL KPSLAPRPTL PPSGNTHRHT LCAKLVDTGY TFSLCGQCAK
LVATGYTFSL CGQCAILFVS DDITLLLGVS VFPIGIGHGY NRAELHMLGS HGNQDNTLHL
NSLEELMMLL TLDKSYVDRL CRGTTTHTTP TTGVNCDRLE PPVCISYMSP VRVEETCGCR
WDCPCVCMGS STNHVVRFDS LALKLDGEGI CSYTLLTVAG GKMVIGGSEV TLHMGTCQGS
ANHNDICMKA MEVTHGLSSV LLKDDMTVTV NGAPVSMPYH SRQVEVMRFG EVMFQLKSVE
HGYILAFTPQ NNEFTLTLSS SSTNHTAGLC GLCGEETVKR LSLRNGSLTL DPALLLSDWS
VPGGEGVCVP RRSPVCVYGA SRACEVLRSE VFSSCHTHVP IMPFITRCQK EACQETDVCD
VISSYTHLCR QRGLCVHWRS SHLCPMQCPS IMEYDACRMG CVEDCRVFRG NKSACMTTPT
EGCFCPQGTV LLGGECVSPD VCNQCVDQHG HRHQYLHTWV PEDNHCQICM CLDYQRINCT
AKPCLDAKAP VCGPCEVLRE KRESKCCPEY ECVCDLVSCE LPEIPRCEDG LTVVLTNPGE
CQPIHQCACK KEECSLQAPP ACPSHRRLSV KQTQCCDSFQ CVCDCHNSTH SCPPGFISSF
STNDCGCTET ACMPDQVCVV GGVVYHVGSQ WEEGCEKCSC TQQRDSHTNL HIAQCVPPVC
DHTCPLGSVY VESQGKCCGS CRKSSCVEND RHTPGDIQTE GRLRKVRGCV WRSPEDMCVL
HQCVSVGDGE VFITHTNVSC PPLDPPPCPL GTELHCDTSA CCPQCHCAPQ DACVLNHTLI
GAGERLMVDM CTHCSCSVED GAVKRYKLSC RRISCPTCPE GYVLEEVPES CCGRCVATAC
IVQQNDGHTI TIQVNTTLTE GCSQFSCGVN SKGELVLKTI LTTCPPFELC ALALCMCNKC
VCVCVCVYVC LCIGTEPECT KMVGTLNYIK VDDCQSQQPI ELHYCEGKCH SKSMYSLETN
SMKKECVCCT AMKTEPLSVP LLCPNGTLTH HNVMSVTACD CQDLHCT
//