ID A0A3P8XEU1_ESOLU Unreviewed; 957 AA.
AC A0A3P8XEU1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Sorting nexin 13 {ECO:0000313|Ensembl:ENSELUP00000001597.2};
GN Name=SNX13 {ECO:0000313|Ensembl:ENSELUP00000001597.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000001597.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000001597.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000001597.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; A0A3P8XEU1; -.
DR STRING; 8010.ENSELUP00000001597; -.
DR Ensembl; ENSELUT00000017123.2; ENSELUP00000001597.2; ENSELUG00000003060.2.
DR GeneTree; ENSGT00950000182856; -.
DR Proteomes; UP000265140; LG10.
DR Bgee; ENSELUG00000003060; Expressed in nose and 15 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06873; PX_SNX13; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037437; SNX13_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 121..306
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 395..535
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 579..701
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 545..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 315..342
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 957 AA; 110365 MW; 57005B1DD140B9D0 CRC64;
MTVSSPLSAS PSLCFVFLHS VSPCLCPQAS LSLWGWGGLG VVLFLITFGP FAIFYLAFYI
FCFVGGGFVV TLLFGKTNSE KHLEKCEHSY LPATQTGIQK TLDEMRLEPK PIKIDRRLTG
SHYIDEPLQQ VIQFALRDYI QYWYYTLSED ESFLLEIRQT VQNALVQFST RSKDVDWQPY
FTTRLVDDFA THLRVFRKAQ DRLEGREDCK QSENMVESFF EAEVEMERNI CRDVVCTSSK
DEEGFLRDLC EVLLYLLLPP GDFHNKNMRY FLREILARGV LLPLINQLSD PDYINQFVIW
MIRDSSCNYE AFMNILKLTD KVAELEAVKD KALEELQYLR SLDTAGDDIN VIKNQINSLL
FVKKVCETRI QRLNSGKEVD ALKLAANFGK LCIIPLEHIL VHNIALQFFM DYMQAAGAQA
ELFFWLTVEG YRVTAQQQLE VMEGWERDGK KGGGTKGLLK AAALGVYEQY LSDKASPRVQ
VDEASVLKLG EKLQKDGDPT PEIFDEIQRK VYDMMLRDDR YYPSFRQSPL YVRMLAELDM
LKEPSYRGSD DGDGGKSGKA PGNPLSLDDL SNSCHDDNLQ LHAFISDTGV CNDHGKTYAL
YAITVFRRNH DGSEETWKTY RRYSDFHDFH MRITEQFDNL TSILKLPGKK TFNNMDRDFL
EKRKKDLNTY LQLLLNPEMV KACPNLVPYV YDFLENKQYS KGKGDFARKM DTFVNPLRSS
MRNVSNAVKG LPDSLAEGMN KAADNMGRMS EKLGQDIKQS MFKVPPMLPK SDIDPEHCRV
SAQLDDNVDD NIPLRVMLLL MDEVFDLKER NQWLRRNIKN LLQQLIRATY GDTINRKIVD
HVDFMTAPEQ VADYVKKFSL RPGLLPRPTC WESCRVTNAH ELKHIIGADT TRKGILRVFD
MFQHGPMNRR LVYVLLEGFL ETMFPQYKFP ELFVKLHSRS PRTTRYTQKL KSTSLKR
//
