ID A0A3P8XF14_ESOLU Unreviewed; 469 AA.
AC A0A3P8XF14;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Rho GTPase-activating protein 15 {ECO:0000256|ARBA:ARBA00040777};
DE AltName: Full=ArhGAP15 {ECO:0000256|ARBA:ARBA00042482};
DE AltName: Full=Rho-type GTPase-activating protein 15 {ECO:0000256|ARBA:ARBA00042925};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000003192.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000003192.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000003192.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR AlphaFoldDB; A0A3P8XF14; -.
DR Ensembl; ENSELUT00000014432.2; ENSELUP00000003192.2; ENSELUG00000004474.2.
DR GeneTree; ENSGT00950000182860; -.
DR Proteomes; UP000265140; LG16.
DR Bgee; ENSELUG00000004474; Expressed in head kidney and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF108; RHO GTPASE-ACTIVATING PROTEIN 15; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 84..195
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 303..469
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 52004 MW; 0C25512F46B4C8FF CRC64;
MAGTRISISG VGKQPPLILP NQLTGAGQGA VQMRIKSSQS SGERLSQSKS MVLQDPDLPP
KPISRHRRNQ SQHNIGGAGA AESPVVLKGE YLNKAKISDG GKKLRKNWTS TWVVLETDQL
LFYKESKQEA LTNLKSGCRP DGVDLCGAMI EWTTERSSRK NVVQITTSSG SEFLLQADNY
PTICKWHDAM KRTAESLSTN AGGQVCGKPG IRRANSTEYL PRHGLSGKTL SLPRPAPESP
SAKESKPEHR RSLIFKSSKL NYSMSDSADK NGVKNRLKKF ITRRPSMKTL QEKGIIKDRV
FGCHLLGLCE REGTTVPKFV RQCVEAVEKR GLDADGIYRV SGNLATIQKL RFLVDQEEEF
NLDDSQWEDI HVVTGALKLF FRELPEPLFP FRFFEPFVEA IKTKEGKQKV QAMKKLVLQL
PKPNQDTMKV LFKHLQRVEN KPLDITSVGV EGEPHPALGG ESKSTCAAA
//
