ID A0A3P8XFK2_ESOLU Unreviewed; 1166 AA.
AC A0A3P8XFK2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=DENN domain-containing protein 5B {ECO:0000313|Ensembl:ENSELUP00000003367.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000003367.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000003367.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000003367.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR AlphaFoldDB; A0A3P8XFK2; -.
DR Ensembl; ENSELUT00000014133.2; ENSELUP00000003367.2; ENSELUG00000004830.2.
DR GeneTree; ENSGT00940000153678; -.
DR Proteomes; UP000265140; LG19.
DR Bgee; ENSELUG00000004830; Expressed in brain and 11 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR Gene3D; 1.20.58.900; -; 2.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070:SF3; DENN DOMAIN-CONTAINING PROTEIN 5B; 1.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 33..536
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 711..838
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 842..950
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1014..1161
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 611..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1166 AA; 131342 MW; A2DFB206FB0D7F1A CRC64;
MTGITSGTGS ASCRFAHYFV VCGLDTKTGL EPEEQAGESF EQSPIRRSFK SKVLAHYPES
TERRPFNRDA VNMLCMPRGL SFRTQTDDRV PFFHSFTVSQ DDGTRFYGFV QTYYEEVTIA
QITMAMQTLH QMHQRPLSAC PCCATGFFQS AQDTLYASKA LCLLTPLPFL QASRHFLTQL
HQAVAASDAP PLPLESYIHN ILYEVPVPPP GRSLRFHGVQ GPIMCQQPGQ EELPLGDYPL
GEAFSLLGVE NLVRLLTSVL LESQVLLLSN DYQRLMTVAE SISTLLFPFQ WWHIYLPVLP
ASLHHLLDAP VPFIIGIQEQ GDTRETLPAP QSANLCFVDI DNHHVDLPED LPLFPDQLEL
IQELNEVLLR FGLQTHAGAT ITNKPDPAAP PCLSSLVLED LMEDRRNGNL GREQLAVLER
LQALARRCGG TAGGKTLGRA FEEEEEELKE AKMNVQLREV FAGRFATLFG RYEEFVIHSA
PDLESWLSNR EGVSNFDKGS FLSTQPTQHL HFLSRFLETA MFSSFVDSKV LSRWADRDPL
QRVFDRRLEK DRLSSPMLVS LCPPAQAVER RLLKADHTAI HPHLLDMRIG QGRHHQGCFP
RLQADVLAQG HNTTKWSGRN ARRSDPRKPV TSPETTSGLD NDLREKYSPG RRSLRQSKLL
DPSPSAVTQT KRGFVDGLLR ECRLKTRRML MERMGKERAE SSQVEAGITG LQENTLIHSI
CVLLERTWAH GLKMKQVRNT HKHTETHSKT GHNLFGTREY KSQRHPTHLG RARAWVYLAL
EKKLLSQHLK LLLTNQDLLR QLYKPHAFLL CEEEREQFLF HLLSLNTVDY FCFTRTFTSI
SIPYRVVIMP MKKLSIAMAM SNPWVCVSGE LGDSGIRQIP KNTQEIYFHC QNLGRLSTLQ
LGQENSGLLA KCLVDCVIVH NEITGHTYRF PCGRWLGKGV GDGSLERVLI GQLVSPGGEE
DSGRWAGTPP EQGSPPQIGL TGLSSVQVQE EIREAVNNLV KHFHKAEPER GNLTALLCGE
VGLVRSLEQF LLHGFKSSRL FQRSVFIWDF VEKAVVSMET ADQMGDLQGS TELCDSMCHY
VNAINATSRN IGKEGKFQLW VCLGVRDQLL SLWLPLLAES HLAARLYEET ALFRDRAAVH
SLSRLLHTLR EFPIALETAL VKGVDL
//
