ID A0A3P8XHV1_ESOLU Unreviewed; 405 AA.
AC A0A3P8XHV1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=G protein-coupled receptor 180 {ECO:0000313|Ensembl:ENSELUP00000003219.2};
GN Name=GPR180 {ECO:0000313|Ensembl:ENSELUP00000003219.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000003219.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000003219.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000003219.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3P8XHV1; -.
DR Ensembl; ENSELUT00000014392.2; ENSELUP00000003219.2; ENSELUG00000004484.2.
DR GeneTree; ENSGT00940000153981; -.
DR Proteomes; UP000265140; LG22.
DR Bgee; ENSELUG00000004484; Expressed in nose and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR047831; GPR180/TMEM145.
DR InterPro; IPR019336; GPR180/TMEM145_TM.
DR PANTHER; PTHR23252:SF29; INTEGRAL MEMBRANE PROTEIN GPR180; 1.
DR PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR Pfam; PF10192; GpcrRhopsn4; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 138..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..372
FT /note="GPR180/TMEM145 transmembrane"
FT /evidence="ECO:0000259|Pfam:PF10192"
SQ SEQUENCE 405 AA; 45001 MW; C369D0D22986E784 CRC64;
SSHISPFPLS RFPSVSSPGG RGLLVCRLEN APLAVEKEAK LLLFPETEEG FDIDNLSCPD
RLSKAQLSIH LSEEEHNQSI PHQSSPTLWM AMYADRYTCG EGGIIPAQGD LAFTVLLFNP
DSAGNPLEHF SAEESGLHSF YCLLILAYFV ASCIYVQPLW RALRKGGPMH TVLKVLSTAL
ALQGVSALFN YIHLARYSRD GDGIPIMGSL AEFCDMVSQV SMLYMLLSLC MGWTLSKNRK
PQSRPLQWDS SPASKALAMG GVATQGALLL WEQYEETEHH SYHAQRSTAG VFLIALRIIL
AVLLASVLYT IIRTERSALK RDFYLSFAKG CFIWFLCHPV LVLLSAIFNE HQREKMVTIG
VILCQAISVV ILYQLFLSRS LYWEVSSLSS VSLPLTMSRG ARGRY
//
