ID A0A3P8XI37_ESOLU Unreviewed; 384 AA.
AC A0A3P8XI37;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Hyaluronan and proteoglycan link protein 1 {ECO:0000256|ARBA:ARBA00040183};
DE AltName: Full=Cartilage-linking protein 1 {ECO:0000256|ARBA:ARBA00042100};
DE AltName: Full=Proteoglycan link protein {ECO:0000256|ARBA:ARBA00042980};
GN Name=HAPLN1 {ECO:0000313|Ensembl:ENSELUP00000004251.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000004251.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000004251.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000004251.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Stabilizes the aggregates of proteoglycan monomers with
CC hyaluronic acid in the extracellular cartilage matrix.
CC {ECO:0000256|ARBA:ARBA00037563}.
CC -!- SIMILARITY: Belongs to the HAPLN family.
CC {ECO:0000256|ARBA:ARBA00038272}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}.
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DR AlphaFoldDB; A0A3P8XI37; -.
DR STRING; 8010.ENSELUP00000004251; -.
DR Ensembl; ENSELUT00000012657.2; ENSELUP00000004251.1; ENSELUG00000005422.2.
DR GeneTree; ENSGT00940000159267; -.
DR InParanoid; A0A3P8XI37; -.
DR OMA; ERACHDQ; -.
DR Proteomes; UP000265140; LG14.
DR Bgee; ENSELUG00000005422; Expressed in bone element and 9 other cell types or tissues.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd05877; Ig_LP_like; 1.
DR CDD; cd03518; Link_domain_HAPLN_module_1; 1.
DR CDD; cd03519; Link_domain_HAPLN_module_2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 2.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000538; Link_dom.
DR PANTHER; PTHR22804; AGGRECAN/VERSICAN PROTEOGLYCAN; 1.
DR PANTHER; PTHR22804:SF10; HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 1; 1.
DR Pfam; PF07686; V-set; 1.
DR Pfam; PF00193; Xlink; 2.
DR PRINTS; PR01265; LINKMODULE.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00445; LINK; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS01241; LINK_1; 1.
DR PROSITE; PS50963; LINK_2; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00323};
KW Hyaluronic acid {ECO:0000256|ARBA:ARBA00023290};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..384
FT /note="Hyaluronan and proteoglycan link protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018144529"
FT DOMAIN 38..155
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 157..251
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DOMAIN 289..381
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DISULFID 203..224
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
FT DISULFID 334..355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
SQ SEQUENCE 384 AA; 43452 MW; 7C0323A75280FD68 CRC64;
MLPVLIWALV SLSLADNLDT AYPELEHYRT IYVQENGPRL SVVTEQSKVV SRRGGNATLP
CKFHRDESLP PNPKLRIKWT KLTSDYLKEV DVFVAMGFHK RSYGSFHGRV YLQNSAPNDA
SLVITELTLE DYGRYKCEVI DALEDGTGVV SLDLQGVVFP YFPRLGRYNL NFFDAERACH
EQDSVVASFD QLYEAWRGGL DWCNAGWLSD GSVQYPITTP REPCGGKNTV PGVRNYGLRD
KDNRYDVFCF TSNYKGEVKE CMQWGSICGL CAQAWLCVCV CKTCPSVSGR FYYLIHPSKL
TYDEAVNACQ KDGAQIAKVG QMYASWKLLG YDRCDAGWLA DGSVRYPITR PRRRCSPTEA
AVRFNGFPDK KHKLYGVYCF KGHN
//
