ID A0A3P8XJ25_ESOLU Unreviewed; 1768 AA.
AC A0A3P8XJ25;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE Short=PARP {ECO:0000256|RuleBase:RU362114};
DE EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000004572.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000004572.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000004572.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
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DR RefSeq; XP_010878606.1; XM_010880304.3.
DR STRING; 8010.ENSELUP00000004572; -.
DR Ensembl; ENSELUT00000012128.2; ENSELUP00000004572.2; ENSELUG00000005711.2.
DR GeneID; 105016442; -.
DR KEGG; els:105016442; -.
DR GeneTree; ENSGT00940000160555; -.
DR InParanoid; A0A3P8XJ25; -.
DR OMA; RQYPCIC; -.
DR OrthoDB; 11548at2759; -.
DR Proteomes; UP000265140; LG16.
DR Bgee; ENSELUG00000005711; Expressed in digestive tract and 15 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 1.20.142.10; Poly(ADP-ribose) polymerase, regulatory domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR031273; PARP4.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR004102; Poly(ADP-ribose)pol_reg_dom.
DR InterPro; IPR036616; Poly(ADP-ribose)pol_reg_dom_sf.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR46530; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4; 1.
DR PANTHER; PTHR46530:SF1; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4; 1.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF13768; VWA_3; 1.
DR SMART; SM00292; BRCT; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF47587; Domain of poly(ADP-ribose) polymerase; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS51060; PARP_ALPHA_HD; 1.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU362114};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU362114};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362114}.
FT DOMAIN 1..92
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 257..389
FT /note="PARP alpha-helical"
FT /evidence="ECO:0000259|PROSITE:PS51060"
FT DOMAIN 388..587
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT DOMAIN 625..753
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 892..1061
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 600..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1363..1392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1768 AA; 195181 MW; 23E24154B8A430E4 CRC64;
MALFDNSFVV LELKNLPYKE KMKLKLAIIE NGGIISYVVN KQCTLVVTTS VSCLSSSRVR
SVEKYQTPVV GVEYVSRCLE EGVLLPVEEY CLDPIPSPFI PRPFSPQSVL TVTSHSAAEQ
RSEVQTLTQV DRAGNQKRTG TYLNKFRVYT ENDQDIPIYP ANFHVAKYSI FQKANCNTWS
VVELQSSRSE AGQQQYRVVR YWREEHAAQS TAVQDKQVFP STSEEAVEVF QSVCQELQVK
GLTQSTTLPP GALDLGSANL HQLLLEEKLS CSSVSQEVGV FVELLWAEAL GCLDNVLKVP
ITSLSLNDVS RAEGLLLQVQ KSLKRRRGGE PDTEVASLME EIYTLLPHKT DLSRPPVQTK
LISSLLDLCQ LITDVLNVSE AMLRSPTSSC LGKYRALRCS IERVPPGPEF LSVTKLLQDR
PVQIMQVLKV TRGVELQMFR EELGNVKPLL HSSSPSSFVG ILSRGLLLPR VGVEHHGIER
TDIGNLGGGI YFSDAMSTSL KYSKPSETDG SRLLLVCDVA LGSCKELQKR DSSLTQAPDG
YHSVHGVRQT SSTASEFEDD EYVVYSQEQV RLHYVVQFRL EDDQLKDFLP NIDTSTELPL
PVSSSDLLSG GEEEEGVGSS KNPLEEVTAG LLDSSGQPLP LQAVHVRARL MDLLSQVIVF
QTYTNQSTVP IEAKYVFPLD DSAAVCGFEA FINGKHVVGQ VKEKQQARKE YKQAIEKGHG
AYLMDQDAPD VFTISVGNLP AGATVLIKVT YITELVVTDG TISFSLPGSV APWQQSSALN
QRTQVTLEKV CVTNLDSRGE FSLAVSIEMP NEIINLHCVG HKVMIKRTDC KAVVKTCPGE
SLGPDGFLLC FGLAQIHLPR MWVEKHPDKD SQACMLVFYP DFEPSSSSGS SEVILLVDSS
ESMRGEALRN ARRIALQLLN NLEKHSVQVN TIFFGTDQKE AFISAQPVVT AQQITKKFIM
SSLPVGGSTE LWRPLRSLSL LPPSQGVRNL LLLSDGHVQN QALTLQLVRE HAQHSRLFTC
GLSPTANQHM LRALAQAGGG TYEFFDTKTM HTWREKVAIQ VKHMMSPGCS SVSVKWQQFN
PRAPPPVQAP SQLHALFSDH QTLVYGFVPH CTQATLLGDV NGQDIETMVS TTELQKTRGT
FLHKLTARAV IRDYEDGCLH INQAEHEGKK AELKSFIIEL SKEFSILSQF TSFVAIEERD
SEQPDVGFTD IPKLISDEDV DFLPYLSWKD GVHEEGVDEE GVHEEGVVEE VYKGICKFKG
GEEVLDMRSC YYACEEEEDY EESGTRGLME SVGPSFGSSE ELCDYSPPRD CDITTMEDSS
SYSSDSDPPP TASPHRQPQS MLGDAFPSRL HRQSQSMLRG AFLCASGPPF PSSPQPQSII
LDSPPPRASK HCKSPRLLLA SDPPSPFKLG HRSFFVAPSP PPPPQPIPPS IDYNILCDAV
PFSSMPSRQS QSASVADVLP PPTSVNGSLS LHLMERYRSS ELTLPSPTAA WSEPLGRAMS
QLPEPIQCDL PKAMGLNYSP SPVHPLPDLS GTGPAGDGEW PSPLVGRTLR KKAKMAAMSY
RPPQGTLFGS RSTSSMTTGT FFGSPALMKA VISTQLPEAA SKFRQWTGAF HTTLYVVKWP
EIFALQHSEG YWECSASLGS LIGVDLDYFA NVVLKEKGIE SLGVRAHADI LRLVASLLVL
QLMRVRGHEV GKLLLSLFRV DLDHSPPQSR NDHWEAVKRA VDWVRWADRE YPCVCSRMEF
GWDWESSTRQ LLGIDPPNPL ISWGVKAQ
//