ID A0A3P8XJ41_ESOLU Unreviewed; 1527 AA.
AC A0A3P8XJ41;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=SH3 and multiple ankyrin repeat domains 2a {ECO:0000313|Ensembl:ENSELUP00000004565.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000004565.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000004565.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000004565.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
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DR STRING; 8010.ENSELUP00000004565; -.
DR Ensembl; ENSELUT00000012143.2; ENSELUP00000004565.2; ENSELUG00000005757.2.
DR GeneTree; ENSGT00940000153561; -.
DR Proteomes; UP000265140; LG02.
DR Bgee; ENSELUG00000005757; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF17; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 165..224
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 267..361
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1464..1527
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 16..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 725..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1377..1410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..531
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..903
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..979
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1032
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1280
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1337..1358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1377..1395
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1527 AA; 163818 MW; 699EEFCB6F88A46C CRC64;
MKSFLNALKK EVPFREAPTY SKRRRAPAPT SSSSSSLVAP RVLLRSNSDN NLTVNQGPSL
DWSQPQGLHR GPQHAVVGTT TSRSLSPQLL QQMPGNPNGT VRTMGRGSHS TSVGMVPRSR
SPSLNRLGEE ARRPQLQTHG QPTLQHREPS NVEVAGQRRK LYSAVPGRHF VVVHPYLPQA
EGEITLYKND RVKVLSIGEG GYWEGSARGQ VGWFPAECVE EIPAKPSDER MHTRADRSDR
RKLFRHYTVG SYDSFDASSD CVVEEKTVVL TKKENEGFGF VLRGAKADTP IEEFTPTPAF
PALQYLESVD EGGVAWQAGL RTGDFLIEVN QENVVKVGHR QVVNMIRHAG NSLVIKVVTV
SRNMDPEDTA RKKAPPPPKR APTTALSMRS KSMTSELEEL VEVSKATLRR KKGDKLDEVS
PSQKAADTKV ATIKPRPSSR CLVTPSDMNS MYDRQGVVAV EPPTVPGSPR GEPFLGIPAK
GGTMRRQKSI GITEEEKTFL TPPPLKFTRS LSMPDTSEDI PPPPDISPPS PPSSYNTASV
TPTPRGYGTT RPGLTLNPSG KCSNANNLSS RTDVGTLRRG YHRQSSEQYD SRSRGRAPVP
ENPYSEVGTK ALYVPAKPAR RKGMLVKQPN VEDSPEKTCL PPTSGALSMP TTPTERTFSS
IPIPTIIVKE PSTSSSGKSS QGSSMEIEPT TPEHPPLAPG SGDKELTAED SMVNNPFAAA
IAGAVRDREK RLEARKNSPG LLSTDLGDED LDDPTPVPRL RQSKSIDEGM FSADEHMRKS
MAPPPAAALL RSQGGSDIGG NVTDFSTPEP TQVVREPLTA RTGTYPNLDS PISLPATPPK
TCSSNGAGGY LHPVTGKALD PNSPLALALA ARDRAMKEQA QMKVPQAPPP SQPQPPPKSD
APQSLPPNSN KPGLNQPLFI DTKLRSGIEA GFASSTTTLG RGRGRGWGMK RQMTEHKYET
DGTAEERQQV ADDRKSTPVD TGDNSQTQQS AGLLMVHTKN RPDGEEGDEE NTPIQDNNIP
SELRDPNQPN PPTNSHSTKP LPPVPQGKSI TATGSVDEIV KLPFHMPPPP LASVDIEEVE
EFVFSEPLPP PLEFANSIDI PEDQATVIAE LLKQRDQDRR NGTGARGPHP PPYSTLPHVS
QFRQGSGMSN CALPPSYPPP PPDSTFEQGV TDSGIEEVDS RSSGDPHMET TSTVSTVSSI
STLSSEGGCD SALENTSMVY TDGQAYLADR PPVPPKPKNK PIINRNTALY HDALMEESLE
SFGTPPPVPP PPPGSLSPPD FPRTPTQRSS KLWGEPPELR SPPTPDPKAT VINELSSILL
QMHRPKPGDS LDSPATGSRG GFGTSSAASG SQRNSGVSFG LPSSACLPPT SLPPHLCSPP
DTSSLSPPPC PSSLPHSASP SLSDVFGLPT PPMGSGSVSA FGSLGGSLGG GSSCGGSRSP
SPLTLMQAVA ASGKPFASKP VEMWSKLDVG DWLDSLNLSE HKEAFMDNEI EGAHLPSLQK
EDLIDLGVTR VGHRMNIERA LKMLQDR
//
