ID A0A3P8XJC8_ESOLU Unreviewed; 848 AA.
AC A0A3P8XJC8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Axin-2 {ECO:0000313|Ensembl:ENSELUP00000028981.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000028981.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000028981.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000028981.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_010895682.1; XM_010897380.3.
DR RefSeq; XP_010895683.1; XM_010897381.3.
DR AlphaFoldDB; A0A3P8XJC8; -.
DR STRING; 8010.ENSELUP00000028981; -.
DR Ensembl; ENSELUT00000011996.2; ENSELUP00000028981.1; ENSELUG00000005769.2.
DR GeneID; 105026129; -.
DR KEGG; els:105026129; -.
DR GeneTree; ENSGT00940000157338; -.
DR InParanoid; A0A3P8XJC8; -.
DR OMA; REMCGAP; -.
DR OrthoDB; 4256282at2759; -.
DR Proteomes; UP000265140; LG11.
DR Bgee; ENSELUG00000005769; Expressed in ovary and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009950; P:dorsal/ventral axis specification; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro.
DR GO; GO:2000054; P:negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd11582; Axin_TNKS_binding; 1.
DR CDD; cd08707; RGS_Axin; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.40.240.130; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR043581; Axin-like.
DR InterPro; IPR014936; Axin_b-cat-bd.
DR InterPro; IPR032101; Axin_TNKS-bd.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46102; AXIN; 1.
DR PANTHER; PTHR46102:SF1; AXIN-2; 1.
DR Pfam; PF16646; AXIN1_TNKS_BD; 1.
DR Pfam; PF08833; Axin_b-cat_bind; 1.
DR Pfam; PF00778; DIX; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00021; DAX; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW ProRule:PRU00069}.
FT DOMAIN 86..205
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 766..848
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 848 AA; 93491 MW; 0E1F89604AD5E15E CRC64;
MSRALMSDHN ASSFREDAPR PPVPGEEGEA PPCFPGKLAM MRPLGTATKA LLLASPSSTA
RRNEDGLGEP EGSASPDSPL ARWTKSLHSL LGDQDGAHLF RTFLEREKCV DTLDFWFACN
GFRQMDLKDT KTLRLAKVIY KRYIDTSSIV AKQLKPATKT FIRDNIKKQQ IDSAMFDQAQ
TEIQSAMEES AYQMFLTSDI YLEYVRSGGE NPAHVNPNGL GSLKLVCGYL PTLNEEEEWS
CNDFKAKALA SVVGLSAKAL RATVSMRTME VMEKGYRRGG PVNPYHVGSF APATSTNDSE
VSSDAMTDDS MSMTDSSVDG IPPFKLGSKK HLQREMHRNM RMNSQVSLPA FPRTQRCPME
MTPVEPAAFA AQLISRLERL KREQETISSL EERLQQIQEE EERDEAEVPG SRAPHPLSLL
PPGSSDEDPQ AILDDHLSRV LKTPGCQSPP AVGRHSPRSR SPERRPLPRG GPGLKPLASP
GASSPSGSSS LGGFPLGFTP ARALTLGRPS TKHIHHHYIH HHATPKSKEQ MEMEAAQKVS
CLCPVRSGGT EGGPLYPRSR SLGRDSPSCG SSTAEANTGR SSSLSRRVCE DGGGEVWPLQ
LPCDGTDRSQ TVWQWILESD RQGKHHKPHS TQSTKKAYGS RAASNQTHTW GGGGASGHHR
THQPVHPFIQ DPAMPPLPPP NTLAQLEEAC RRLEEVSVSN PPKQRHCTSS LQREKSQPVP
VESGVCPALS PLSPGPATHQ SEELKEPSRF QQHQVAAGCR VAPAMGKETV VTYFFCGEEI
PYRRMMKTHR LTLGHFKEQL RKKGHYRYYF KKASDEFECG AVFEEVWDDS SMLPMYEGKI
LGKVERVD
//
